Acquisition and Retention of Motor Memories in Adults and Typically Developing Children

NCT04598945 | Unknown

• 1 other identifier: 38RC20.005
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Our motor skills require motor memories without which our behavior is only reflexes and stereotypies. The way which these memories form in the human brain constitute therefore a major challenge for neuroscience research. Some a lot of evidence suggests that any new motor skills is acquired in the cerebellum and then persisted in the cortex. This vision seems however caricature, the formation of memories motor probably requiring complex remodeling of cortico-cerebellar networks. The MotorMemo project aspires to better understand this remodeling, by testing more specifically the hypothesis of cerebellar weakening and strengthening cortical as a substrate for the formation of motor memories. A longitudinal study using a sensorimotor adaptation protocol, fMRI as well as a developmental perspective is proposed to verify this hypothesis.

Conditions

Memory

Outcome Measures

Primary Outcomes (1)

• Evaluate, in adults and children, whether the acquisition and retention of a new internal movement pattern are linked to the activation of a large cortico-cerebellar network ladder.

  Change in cerebellar activation and cortical induced by the visuomotor adaptation task compared to a task motor control not requiring adaptation

  3 days

Study Arms (2)

Adults

EXPERIMENTAL

The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence.

Other: Functionel MRI

Children

EXPERIMENTAL

The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence.

Other: Functionel MRI

Interventions

Functionel MRI OTHER

During the activation fMRI sequences, the subject will perform target pointing tasks, that is to say that he will have to reach, by controlling a cursor using a non-magnetic joystick, targets projected onto a display screen. In each of the pointing tasks he will have to reach the target as quickly and as precisely as possible, and stay in the center of it for a long time times reached.

Adults; Children

Eligibility Criteria

• Age: 8 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• right-handed
• affiliated to a social security scheme
• who gave their consent to participate in the study

You may not qualify if:

• Contraindication to MRI
• visual impairment;
• suffering from one of the following pathologies:
• dysphasia,
• ADHD,
• dyspraxia,
• dyslexia,
• dysorthography,
• dyscalculia;
• history of epilepsy
• subject under administrative or judicial supervision
• pregnant or breastfeeding women
• Persons referred to in articles l1121-8

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• TIMC-IMAG: collaborator

Study Sites (1)

CHU Grenoble-Alpes

Grenoble, 38043, France

RECRUITING

Central Study Contacts

Fabien CIGNETTI, phD

CONTACT

04 76 63 71 10; fabien.cignetti@univ-grenoble-alpes.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 16, 2020
• First Posted: October 22, 2020
• Study Start: October 20, 2020
• Primary Completion: October 1, 2022
• Study Completion: November 1, 2022
• Last Updated: November 17, 2020

Record last verified: 2020-11

Locations

FR (1)