Digital Wavefront Sensing
DWS
Reproducibility and Comparison of Digital Wavefront Sensing With Conventional Shack-Hartmann Wavefront Sensing: an Explorative Study
1 other identifier
interventional
30
0 countries
N/A
Brief Summary
A holographic optical coherence tomography (H-OCT) setup is used to detect the wavefront by means of phase reconstruction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Dec 2020
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 15, 2020
CompletedFirst Posted
Study publicly available on registry
October 22, 2020
CompletedStudy Start
First participant enrolled
December 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2021
CompletedOctober 22, 2020
October 1, 2020
1 year
October 15, 2020
October 15, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Qualitative description of lower order aberrations (LOA)
Zernike terms, RMS-error, Strehl ratio
14 +/- 3 days
Qualitative description of higher order aberrations (HOA)
Zernike terms, root mean square error , Strehl ratio
14 +/- 3 days
Study Arms (1)
Holographic optical coherence tomography
EXPERIMENTALHealthy phakic participants
Interventions
Descriptive wavefront analysis with holographic optical coherence tomography
Eligibility Criteria
You may qualify if:
- Informed consent
- Men and women aged between 18 and 85 years
- Normal ophthalmic findings except refractive errors or suspected higher order aberrations
- Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
You may not qualify if:
- Hyperopia \> +6 Dpt. and Myopia \< -6 Dpt.
- Known ophthalmic diseases such as age related macular degeneration, diabetic retinopathy, glaucoma, retinal detachment or previous ocular trauma and surgeries except cataract extraction
- Participation in a clinical trial in the previous 3 weeks
- Presence of any abnormalities preventing reliable measurements as judged by the investigator
- Pregnancy, planned pregnancy or lactating
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (3)
Kumar A, Drexler W, Leitgeb RA. Subaperture correlation based digital adaptive optics for full field optical coherence tomography. Opt Express. 2013 May 6;21(9):10850-66. doi: 10.1364/OE.21.010850.
PMID: 23669942BACKGROUNDLiang J, Grimm B, Goelz S, Bille JF. Objective measurement of wave aberrations of the human eye with the use of a Hartmann-Shack wave-front sensor. J Opt Soc Am A Opt Image Sci Vis. 1994 Jul;11(7):1949-57. doi: 10.1364/josaa.11.001949.
PMID: 8071736BACKGROUNDKumar A, Wurster LM, Salas M, Ginner L, Drexler W, Leitgeb RA. In-vivo digital wavefront sensing using swept source OCT. Biomed Opt Express. 2017 Jun 21;8(7):3369-3382. doi: 10.1364/BOE.8.003369. eCollection 2017 Jul 1.
PMID: 28717573BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Rainer Leitgeb, Prof.
Meidcal University of Vienna
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Doreen Schmidl [dschmidl]
Study Record Dates
First Submitted
October 15, 2020
First Posted
October 22, 2020
Study Start
December 1, 2020
Primary Completion
December 1, 2021
Study Completion
December 1, 2021
Last Updated
October 22, 2020
Record last verified: 2020-10