Testing Multiple Behavioral Science Strategies to Increase Flu-Shot Rates at a Large Retail Pharmacy
1 other identifier
interventional
734,383
1 country
1
Brief Summary
This research aims to identify which behavioral science strategies are most effective at increasing flu vaccination rates overall and based on patients' individual characteristics. Past behavioral science interventions have shown promise in increasing flu vaccinations. For example, successful interventions have encouraged people to make concrete plans for when they will get a flu vaccination, sent automated calls or text messages reminding patients to get a flu vaccination , or provided financial incentives for getting vaccinated. Although these results are promising, these studies have been conducted in isolation on different populations, which makes it difficult to compare their interventions' effectiveness or to have enough power to reliably detect differing responses to interventions based on individual characteristics. This research will simultaneously test 22 different SMS interventions to increase flu vaccinations compared to a holdout control condition in a "mega-study" and apply machine learning to identify which interventions work best for whom. The interventions are designed by behavioral science experts from the Behavior Change for Good Initiative (BCFG), Penn Medicine Nudge Unit (PMNU), and Geisinger Behavioral Insights Team (BIT). Customers of a large retail pharmacy who received a flu shot from the pharmacy last year and receive SMS notifications will be included in this study. We expect this to include approximately 1.2 million participants. The specific aims of this research are to identify (1) which behavioral science strategies effectively increase flu vaccination rates overall, and (2) which strategies are most effective for different subgroups (e.g., based on age, gender, race).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2020
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 25, 2020
CompletedFirst Submitted
Initial submission to the registry
October 2, 2020
CompletedFirst Posted
Study publicly available on registry
October 19, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2020
CompletedFebruary 1, 2021
January 1, 2021
3 months
October 2, 2020
January 29, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Whether participants receive a flu shot vaccination at our pharmacy partner by December 31, 2020
The primary outcome measure is whether participants receive a flu shot at our retail pharmacy partner by December 31, 2020 (as recorded in their pharmacy records) after receiving the SMS intervention on September 25, 2020. Participants who receive a flu shot before September 25, 2020 when they received the SMS intervention will be excluded from the analyses.
98 days
Secondary Outcomes (1)
Whether participants receive a flu shot vaccination at our pharmacy partner by October 31, 2020
37 days
Study Arms (23)
Holdout control
NO INTERVENTIONParticipants will only receive the standard pharmacy messaging.
Unpacking Risks Treatment
EXPERIMENTALParticipants will be asked to think about the risks of catching the flu this flu season and to respond with the location they are most likely to catch the flu out of a list of given options (e.g. at work, at home).
Unpacking Risks Control
EXPERIMENTALParticipants will be asked to think about the risks of catching the flu this flu season and to respond to confirm that they have received the message.
Active Commitment Treatment
EXPERIMENTALParticipants receive a gain framed notification that they are eligible for a flu shot. In addition, participants are told "Many people find it helpful to make a plan to get their shot" and are asked to commit by texting back "I will get a flu shot." Depending on their response, participants receive a general reminder or a commitment reminder 3 days later.
Active Commitment Control
EXPERIMENTALParticipants receive a gain framed notification that they are eligible for a flu shot. Participants receive a general reminder 3 days later.
Self-Generated Social Norms Treatment
EXPERIMENTALParticipants will first receive a message enjoining them to consider 2 peers who would want them to vaccinate. Then they will be asked to do those peers a favor by getting a vaccine at their next opportunity. They will receive a reminder 3 days later.
Self-Generated Social Norms Control
EXPERIMENTALarticipants will be informed of the opportunity to receive a flu vaccine at their appointment. They will receive a reminder 3 days later.
Foot-in-the-Door Treatment
EXPERIMENTALParticipants will first receive a message enjoining them to encourage someone else to receive a flu vaccine this year. They will then be given a message that they might copy-paste to forward to friends, thereby lowering the effort costs of messaging others. They will receive a reminder 3 days later.
Foot-in-the-Door Control
EXPERIMENTALParticipants will be informed of the opportunity to receive a flu vaccine at their appointment. They will receive a reminder 3 days later.
Prosocial Condition
EXPERIMENTALParticipants will receive a message describing the condition-specific benefit of getting a flu shot, and a reminder to ask for their flu shot. The message will also give prosocial reasons for vaccinating (i.e., protecting loved ones; preserving scarce resources).
Self-Oriented Condition
EXPERIMENTALParticipants will receive a message describing the condition-specific benefit of getting a flu shot, and a reminder to ask for their flu shot.
Prosocial + COVID-19
EXPERIMENTALParticipants will receive a message describing the condition-specific benefit of getting a flu shot, and a reminder to ask for their flu shot. The message will also give prosocial reasons for vaccinating (e.g., protecting loved ones; preserving scarce resources). The message will also emphasize the pandemic (e.g., risk of hospital-acquired COVID-19 infection; wasting scarce resources).
Self-Oriented + COVID-19
EXPERIMENTALParticipants will receive a message describing the condition-specific benefit of getting a flu shot, and a reminder to ask for their flu shot. The message will also emphasize the pandemic (e.g., risk of hospital-acquired COVID-19 infection; wasting scarce resources).
Dynamic + Static Norm
EXPERIMENTALParticipants will receive a text message encouraging them to get a flu shot and informing them that more American adults are getting their flu shot than ever before and how many Americans got their flu shot last year.
Dynamic Norm
EXPERIMENTALParticipants will receive a text message encouraging them to get a flu shot and informing them that more American adults are getting their flu shot than ever before.
Dynamic Norms Control
EXPERIMENTALParticipants will only receive a text message encouraging them to get a flu shot. They will not receive any norm information.
Sharing Humor
EXPERIMENTALParticipants will receive a text message encouraging them to get the flu shot. The message will include a joke about the flu and will encourage participants to share the joke with nurses, doctors, or pharmacists.
Humor Placebo
EXPERIMENTALParticipants will receive a text message encouraging them to get the flu shot. This message will include the same joke but participants will not be encouraged to share it.
No Humor Condition
EXPERIMENTALParticipants will receive a text message encouraging them to get the flu shot.
Connecting the Past Self to the Future Self Treatment
EXPERIMENTALParticipants will receive a text message prompt to recall the negative experience of getting sick. When asked, "Do you wish you could have avoided getting sick by getting a simple shot?", participants will have the chance to respond Y for yes or N for no. Regardless of their response, they will be prompted with a second text message to connect their past experience with present-day opportunities for preventative care (getting a flu shot) to protect the future self from the flu.
Connecting the Past Self to the Future Self Control
EXPERIMENTALIn the first text message, participants will receive a simple text message encouragement to receive a flu shot. In the second text message, they will receive a reminder of the appointment time and provider name.
Reverse Inference Condition
EXPERIMENTALParticipants will receive a text message encouraging them to get a flu shot and informing them that Americans who get flu shots are healthier, wealthier, and more educated.
Reverse Inference Control Condition
EXPERIMENTALParticipants will receive a text message encouraging them to get a flu shot and informing them that Americans who get flu shots are less likely to get the flu.
Interventions
Participants will receive text messages per descriptions listed in the arms.
Eligibility Criteria
You may qualify if:
- Have agreed to receive SMS messages from the pharmacy
- Received a flu shot from the pharmacy in the 2019-2020 flu season, as documented in their pharmacy records.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
Related Publications (4)
Cutrona SL, Golden JG, Goff SL, Ogarek J, Barton B, Fisher L, Preusse P, Sundaresan D, Garber L, Mazor KM. Improving Rates of Outpatient Influenza Vaccination Through EHR Portal Messages and Interactive Automated Calls: A Randomized Controlled Trial. J Gen Intern Med. 2018 May;33(5):659-667. doi: 10.1007/s11606-017-4266-9. Epub 2018 Jan 30.
PMID: 29383550BACKGROUNDMilkman KL, Beshears J, Choi JJ, Laibson D, Madrian BC. Using implementation intentions prompts to enhance influenza vaccination rates. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10415-20. doi: 10.1073/pnas.1103170108. Epub 2011 Jun 13.
PMID: 21670283BACKGROUNDRegan AK, Bloomfield L, Peters I, Effler PV. Randomized Controlled Trial of Text Message Reminders for Increasing Influenza Vaccination. Ann Fam Med. 2017 Nov;15(6):507-514. doi: 10.1370/afm.2120.
PMID: 29133488BACKGROUNDNowalk MP, Lin CJ, Toback SL, Rousculp MD, Eby C, Raymund M, Zimmerman RK. Improving influenza vaccination rates in the workplace: a randomized trial. Am J Prev Med. 2010 Mar;38(3):237-46. doi: 10.1016/j.amepre.2009.11.011. Epub 2009 Dec 24.
PMID: 20036102BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- CARE PROVIDER, OUTCOMES ASSESSOR
- Masking Details
- As treated participants will receive text messages, there is no scope for blinding. Care providers will not be made aware of subjects' participation in the study, or assigned treatment arms. The study team will only receive data on subjects' assigned arms and outcomes at the end of the study.
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 2, 2020
First Posted
October 19, 2020
Study Start
September 25, 2020
Primary Completion
December 31, 2020
Study Completion
December 31, 2020
Last Updated
February 1, 2021
Record last verified: 2021-01
Data Sharing
- IPD Sharing
- Will not share