The Effect of Transcranial Direct Current Stimulation on Motor Performance in Healthy Adults

NCT04577768 | Completed

• 1 other identifier: AU-HEA-SFT-20190326
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

to investigate the effect of stimulation intensity on motor performance in healthy adults.

Conditions

Healthy

Keywords

transcranial direct current stimulation; motor performance

Outcome Measures

Primary Outcomes (12)

• Change in movement time (s) from baseline to intervention

  Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.

  Baseline (immediately before stimulation), two minutes after starting the stimulation

• Change in movement time (s) from baseline to posttest

  Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.

  Baseline (immediately before stimulation), immediately post stimulation

• Change in movement time (s) from baseline to retention test

  Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.

  Baseline (immediately before stimulation), 24 hours following the stimulation

• Change in movement time (s) from intervention to posttest

  Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.

  Two minutes after starting the stimulation, immediately post stimulation

• Change in movement time (s) from intervention to retention test

  Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.

  Two minutes after starting the stimulation, 24 hours following the stimulation

• Change in movement time (s) from posttest to retention test

  Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.

  immediately post stimulation, 24 hours following the stimulation

• Change in reaction time (s) from baseline to intervention

  Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.

  Baseline (immediately before stimulation), two minutes after starting the stimulation

• Change in reaction time (s) from baseline to posttest

  Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.

  Baseline (immediately before stimulation), immediately post stimulation

• Change in reaction time (s) from baseline to retention test

  Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.

  Baseline (immediately before stimulation), 24 hours following the stimulation

• Change in reaction time (s) from intervention to posttest

  Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.

  Two minutes after starting the stimulation, immediately post stimulation

• Change in reaction time (s) from intervention to retention test

  Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.

  Two minutes after starting the stimulation, 24 hours following the stimulation

• Change in reaction time (s) from posttest to retention test

  Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.

  immediately post stimulation, 24 hours following the stimulation

Study Arms (3)

HD-tDCS 2 mA

EXPERIMENTAL

Single session of 20-min HD-tDCS to the right primary motor cortex with an intensity of 2 mA. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.

Device: HD-tDCS 2 mA

HD-tDCS 1.5 mA

EXPERIMENTAL

Single session of 20-min HD-tDCS to the right primary motor cortex with an intensity of 1.5 mA. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.

Device: HD-tDCS 1.5 mA

Control

SHAM COMPARATOR

Single session of 20-min of sham HD-tDCS. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.

Device: HD-tDCS sham

Interventions

HD-tDCS 2 mA DEVICE

anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 2 mA

HD-tDCS 2 mA

HD-tDCS 1.5 mA DEVICE

anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 1.5 mA

HD-tDCS 1.5 mA

HD-tDCS sham DEVICE

sham stimulation of the right primary motor cortex

Control

Eligibility Criteria

• Age: 20 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• aged between 20 and 35
• right-hand dominant
• healthy according to self report

You may not qualify if:

• taking psychiatric medications
• a history of drug abuse or dependence
• psychiatric or neurological disorder
• a history of seizures
• metal implants in their head
• musculoskeletal deficits interfering with task performance (proper reaching performance in sitting)

Sponsors & Collaborators

• Ariel University: lead
• Tel Aviv University: collaborator

Study Sites (1)

Ariel University

Ariel, Israel

Location

Related Publications (1)

• Lerner O, Friedman J, Frenkel-Toledo S. The effect of high-definition transcranial direct current stimulation intensity on motor performance in healthy adults: a randomized controlled trial. J Neuroeng Rehabil. 2021 Jun 26;18(1):103. doi: 10.1186/s12984-021-00899-z.

  PMID: 34174914 DERIVED

Study Officials

• Silvi Frenkel-Toledo

  Ariel University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: randomized controlled trial (RCT)

Study Record Dates

• First Submitted: September 23, 2020
• First Posted: October 8, 2020
• Study Start: July 11, 2019
• Primary Completion: February 10, 2020
• Study Completion: February 10, 2020
• Last Updated: October 8, 2020

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)