Age-Related Changes and Cycloplegia-Induced Differences in the Human Crystalline Lens
1 other identifier
observational
129
1 country
1
Brief Summary
The ocular biometric parameters of the human crystalline lens including anterior chamber depth (ACD), lens thickness (LT), radii of curvature of anterior and posterior lens (ALR and PLR), lens equatorial diameter (LED), and lens vault (LV), automatically quantified by the CASIA2 (SS-OCT; Tomey, Nagoya, Japan). Images of iridocorneal angle were obtained using CASIA2 and the Schlemm' s canal (SC) and trabecular meshwork (TM) were quantified manually. Both cycloplegia and non-cycloplegia images were obtained.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
January 30, 2020
CompletedFirst Submitted
Initial submission to the registry
September 21, 2020
CompletedFirst Posted
Study publicly available on registry
October 6, 2020
CompletedOctober 6, 2020
September 1, 2020
2 months
September 21, 2020
September 30, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Paired Comparison Before and After Cycloplegia
The cycloplegia-induced differences of parameters was defined as: the post-cycloplegic value minus the pre-cycloplegic value.
2020.2.3
Evaluated the effect of age on the TM/SC morphologies
The age-related variations of TM/SC parameters from four age groups were compared.
2020.2.3
Secondary Outcomes (1)
Evaluated the effect of age on the ocular biometric data
2020.2.3
Study Arms (4)
Group 1
participants of less than 18 years old
Group 2
participants aged from 18 years to 40 year
Group 3
participants aged from 41 years to 60 years
Group 4
participants over 60 years old
Eligibility Criteria
Healthy individuals aged between 6 and 90 years, without history of ocular disease (except age-related cataract and/or myopia) at Eye hospital of Wenzhou Medical University
You may qualify if:
- Healthy individuals aged between 6 and 90 years, without history of ocular disease (except age-related cataract and/or myopia) Must be able to cooperate examination
You may not qualify if:
- ocular diseases other than cataracts history of eye surgeries or injuries shallow anterior chamber with a risk of angle closure
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ophthalmology and Optometry Hospital
Wenzhou, Zhejiang, 325027, China
Related Publications (1)
Li Z, Meng Z, Qu W, Li X, Chang P, Wang D, Zhao Y. The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm's Canal: An in vivo Swept-Source Optical Coherence Tomography Study. Front Physiol. 2021 Nov 19;12:763736. doi: 10.3389/fphys.2021.763736. eCollection 2021.
PMID: 34867468DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Yune Zhao
Ophthalmology and Optometry Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Vice president of Eye Hospital of Wenzhou Medical University
Study Record Dates
First Submitted
September 21, 2020
First Posted
October 6, 2020
Study Start
April 1, 2019
Primary Completion
May 31, 2019
Study Completion
January 30, 2020
Last Updated
October 6, 2020
Record last verified: 2020-09