MSSA and MRSA Screening in Patients Undergoing Elective TJA: the Benefits of Next-generation Sequencing

NCT04574752 | Unknown

• 1 other identifier: JPARV20D.165
• Study Type: observational
• Target: 163
• Locations: 1 country
• Sites: 1

Brief Summary

The aims of this study were to evaluate the diagnostic performance of molecular and culture techniques in S. aureus screening using paired nasal and groin swabs, to determine, if any, discrepancy between the diagnostic techniques and to model the potential effect of different diagnostic techniques on S. aureus detection in orthopaedic patients

Conditions

Staphylococcus Aureus; Next Generation Sequencing; Total Joint Arthroplasty

Outcome Measures

Primary Outcomes (1)

• Diagnostic techniques to identify S. aureus in total joint replacement patients

  to model the potential effect of different diagnostic techniques on S. aureus detection in orthopaedic patients.

  1 day

Interventions

next generation sequencing DIAGNOSTIC_TEST

diagnostic performance of molecular and culture techniques in S. aureus screening using paired nasal and groin swabs, to determine, if any, discrepancy between the diagnostic techniques on S. aureus detection in orthopaedic patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients undergoing primary total knee or total hip arthroplasty at our institution will be eligible

You may qualify if:

• All patients undergoing primary total knee or total hip arthroplasty at our institution will be eligible.

You may not qualify if:

• Patients included in other prospective studies

Sponsors & Collaborators

• Rothman Institute Orthopaedics: lead

Study Sites (1)

Rothman Orthopaedic Institute

Philadelphia, Pennsylvania, 19107, United States

Location

MeSH Terms

Conditions

Staphylococcal Infections

Condition Hierarchy (Ancestors)

Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 29, 2020
• First Posted: October 5, 2020
• Study Start: August 30, 2020
• Primary Completion: August 30, 2021
• Study Completion: August 30, 2021
• Last Updated: October 5, 2020

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)