Does the Air-bubble Location Influence on the Implantation Rate
TRANSFER
Evaluation of the Implantation Rate Depending on the Air Bubble Location Through Ultrasound Into the Uterine Cavity in Pre-embryo Transfer
1 other identifier
observational
400
0 countries
N/A
Brief Summary
The main objective of the study is to evaluate whether there is any association between the location into the uterine cavity, where the air bubbles containing the pre-embryos were placed, and the implantation rate. Therefore, the images generated during pre-embryos transfer are available in our database and studied retrospectively.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2013
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 20, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 25, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
October 25, 2019
CompletedFirst Submitted
Initial submission to the registry
September 28, 2020
CompletedFirst Posted
Study publicly available on registry
October 5, 2020
CompletedOctober 6, 2020
October 1, 2020
6.1 years
September 28, 2020
October 2, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Implantation rate
Analyze Implantation rate in the groups
Since September 2013 October 2019
Study Arms (3)
Frozen embryo transfer (FET)
Collect retrospectively data on embryo implantation rate
Intracytoplasmic sperm injection (ICSI)
Collect retrospectively data on embryo implantation rate
oocyte donation
Collect retrospectively data on embryo implantation rate
Interventions
Collect retrospectively data on embryo implantation rate
Eligibility Criteria
IVIVigo patients with a normal uterine anatomy and a single good quality embryo to transfer at blastocyst stage, performed by the same gynaecologist using the "three-drop technique" were included. All transfer were atraumatic, without blood presence, using soft catheter and with controlled ultrasound transfer. The distance between the fundus surface and the tip of catheter, the distance between the fundus and the air bubble, the endometrial thickness and the implantation rate were recorded.
You may qualify if:
- Patients with normal uterine anatomy, who underwent an ultrasound guided embryo transfer.
- BMI\< 30kg/m2.
- Ultrasound guided embryo transfer made by the same researcher.
You may not qualify if:
- Presence of uterine fibroid in the anterior uterine body that make difficult the transfer visualization.
- Asherman Syndrome.
- Adenomyosis that reduces the uterine cavity visibility.
- Difficult transfers where the use of a semi-rigid cannula sheath is needed to entry into the uterine cavity.
- Previous uterine surgery that alters its anatomy.
- Istmocele
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- IVI Vigolead
Related Publications (1)
Friedman BE, Lathi RB, Henne MB, Fisher SL, Milki AA. The effect of air bubble position after blastocyst transfer on pregnancy rates in IVF cycles. Fertil Steril. 2011 Mar 1;95(3):944-7. doi: 10.1016/j.fertnstert.2010.07.1063.
PMID: 20810105BACKGROUND
Study Officials
- PRINCIPAL INVESTIGATOR
Ekin DR Muñoz, MD
IVI Vigo
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 28, 2020
First Posted
October 5, 2020
Study Start
September 20, 2013
Primary Completion
October 25, 2019
Study Completion
October 25, 2019
Last Updated
October 6, 2020
Record last verified: 2020-10
Data Sharing
- IPD Sharing
- Will not share