The Noninvasive Ventilation to COVID-19 Patients

NCT04568655 | Completed DMC

• 1 other identifier: FAHGuangzhouYLS03
• Study Type: observational
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

Noninvasive ventilation(NIV) is an important treatment to the respiratory failure patients.The severe Corona Virus Disease-19(COVID-19) patients are incline to respiratory failure.The NIV may reduce the intubtion rate.This research was taken to investigate the factor to the success of the noninvasive ventilation to the COVID-19 patients with respiratory failure.

Conditions

Noninvavie Ventilation to Patients With COVID-19

Keywords

noninvavie ventilation; COVID-19; respiratory failure

Outcome Measures

Primary Outcomes (2)

• success rate

  the sucess rate of the noninvasive ventilation

  4 month

• the intubtion rate

  the intubtion rate of the COVID-19 patients

  4 month

Secondary Outcomes (4)

• blood lymphocyte

  4month

• B-type natriuretic peptide

  4 month

• Procalcitonin

  4 month

• Oxygen Saturation

  4 month

Study Arms (1)

COVID-19 patients need noninvasive ventilation

Device: noninvasive ventilation

Interventions

noninvasive ventilation DEVICE

noninvasive ventilation to support the COVID-19 patients with respiratory failure

COVID-19 patients need noninvasive ventilation

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

respiratory failure patients with COVID-19

You may qualify if:

• Shortness of breath, RR\>30 times per minute;
• At room air, SpO2 lower than 93%;
• The partial pressure of Arterial blood oxygen (PaO2)/the fraction of inspired oxygen (FiO2) ≤ 300mmHg;
• CT（computed tomography） chest imaging shows that lung damage develops significantly within 24 to 48 hours.

You may not qualify if:

• Severe cardiovascular disease,
• respiratory arrest,
• cardiovascular instability (hypotension, arrhythmias, myocardial infarction),
• change in mental status or patients who were uncooperative, high risk of aspiration, viscous or copious
• secretions,
• recent facial or gastroesophageal surgery,
• craniofacial trauma, 8)fixed nasopharyngeal abnormalities,
• ）burns, 10) extreme obesity.

Sponsors & Collaborators

• The First Affiliated Hospital of Guangzhou Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 520120, China

Location

MeSH Terms

Conditions

COVID-19; Respiratory Insufficiency

Interventions

Noninvasive Ventilation

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Intervention Hierarchy (Ancestors)

Respiration, Artificial; Airway Management; Therapeutics; Respiratory Therapy

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: The First Affiliated Hospital of Guangzhou Medical University

Study Record Dates

• First Submitted: September 28, 2020
• First Posted: September 29, 2020
• Study Start: February 1, 2020
• Primary Completion: July 1, 2020
• Study Completion: July 1, 2020
• Last Updated: September 29, 2020

Record last verified: 2020-09

Locations

CN (1)