Representational Approach to Hippocampal Functions : a fMRI Study

NCT04562974 | Completed

• 1 other identifier: 2020-A01592-37
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Although traditional neuropsychological models associate medial temporal lobe (MTL) regions to memory, and the hippocampus to episodic memory, there is growing evidence supporting an alternative view. The representational view of the MTL proposes that such regions depends on the representations processed rather than the cognitive processes. The aim of this project is to characterise the role played by MTL areas, and particularly the hippocampus, in mnemonic and non-mnemonic cognition. Hypotheses stemming from the representational view will thus be tested, using functional MRI among young healthy participants.

Conditions

Memory, Episodic; Form Perception

Keywords

memory; neuropsychology; hippocampus; perception; neuroimaging

Outcome Measures

Primary Outcomes (1)

• Hippocampal activity during behavioural tasks in the MRI scanner

  Activity will be recorded through the MRI whereas participants will perform the tasks. Outcome criteria consist in significant activity observed in participants hippocampus, depending on the experimental conditions.

  through study completion, an average of 1 year

Study Arms (1)

One group of 30 healthy subjects

EXPERIMENTAL

Perception and memory tasks inside a MRI-scanner for all participants

Device: MRI-scanner

Interventions

MRI-scanner DEVICE

Only one group of 30 participants is constituted. All participants will perform perception and memory tasks inside a MRI-scanner. Functional activity (BOLD signal) will be registered, as well as anatomical and behavioural data.

One group of 30 healthy subjects

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Affiliation to French Healthcare system
• No contraindication to MRI examination
• Age between 18 and 35 years-old
• Visual acuity permitting normal perception of stimuli or corrected sight

You may not qualify if:

• Existence of a pathology incompatible with the protocol : Heart, respiratory, haematological, caner, neurological disorder...
• Brain-modulating medical treatment
• Alcohol intake before examination
• Uncorrected visual disorder
• Cognitive deficit (criterion MMSE \< 27)
• People protected by articles L1121-5 to L1121-8 of the CSP (pregnant women, under-18 subjects, people under judiciary or administrative surveillance)

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• Laboratoire de Psychologie et NeuroCognition: collaborator
• University Grenoble Alps: collaborator
• Université Savoie Mont Blanc: collaborator

Study Sites (1)

Chu Grenoble Alpes

Grenoble, 38043, France

Location

Related Publications (1)

• Gardette J, Cousin E, Bourgin J, Torlay L, Pichat C, Moreaud O, Hot P. Hippocampal activity during memory and visual perception: The role of representational content. Cortex. 2022 Dec;157:14-29. doi: 10.1016/j.cortex.2022.09.004. Epub 2022 Sep 28.

  PMID: 36272329 RESULT

MeSH Terms

Conditions

Recurrence

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Olivier Moreaud

  University Hospital, Grenoble

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 4, 2020
• First Posted: September 24, 2020
• Study Start: September 3, 2021
• Primary Completion: March 2, 2022
• Study Completion: March 2, 2022
• Last Updated: December 22, 2025

Record last verified: 2025-12

Locations

FR (1)