Reverse King-Devick Test and History of Multiple Concussions
Effects of Reading Direction and History of Multiple Concussions on King-Devick Test
1 other identifier
interventional
71
1 country
1
Brief Summary
The purpose of this study is to examine the effects of concussion history and reading direction on baseline King- Devick Test (KDT) performance, a common component of sideline concussion assessments. The KDT is a timed assessment of saccades, or quick movements of the eyes between two points. This test is a form of rapid automatized naming and involved subjects reading digits arranged on a tablet screen as quickly and accurately as possible. The test has three progressively more challenging test "cards," as the horizontal guidelines between digits disappear from test card 1 to 2, and the vertical spacing between the lines of digits decreases from test card 2 to 3. KDT performance is evaluated in terms of both speed (duration to all three test cards) and the number of errors (digits read incorrectly or omitted). Previous studies have identified several factors that affect KDT performance aside from head injury, including age, sex, sleep deprivation, learning disabilities, and first languages other than English. History of concussion has not been shown to influence KDT performance. The investigators hypothesize that since the left-to-right (L-R) reading direction of the KDT is the same way in which to read English, the long-term effects of prior concussions on saccadic eye movements may be masked. The investigators want to answer the following three research questions: 1) What is the effect of KDT reading direction on baseline KDT performance? If the test is performed by reading digits in a right-to-left (R-L) direction, will KDT times be slower and the number of errors increase relative to a typical L-R KDT? 2) What is the effect of a history of multiple concussions on KDT performance relative to no history of concussion? 3) Is the R-L KDT more sensitive to a history of multiple concussions? The investigators hypothesize that individuals with a history of multiple concussions will perform significantly worse (longer test durations, more errors) than individuals with no concussion history on the R-L KDT. On the other hand, the investigators hypothesize that baseline performance on the traditional L-R KDT will not be able to discriminate individuals with a history of multiple concussions from those with no concussion history.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 13, 2020
CompletedStudy Start
First participant enrolled
September 20, 2020
CompletedFirst Posted
Study publicly available on registry
September 23, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2022
CompletedFebruary 23, 2023
February 1, 2023
1.6 years
September 13, 2020
February 21, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
Between-group difference King-Devick test speed between conventional and reverse direction
The comparison in King-Devick test speed (in second) between conventional reading direction of King-Devick test and reverse direction of King-Devick test will be made in each group (multiple concussion history, single concussion history, and no concussion history).
Within 10 years of last concussion
ROC diagnostic accuracy of reverse King-Devick test to differentiate concussion history
ROC test will be performed to test the diagnostic accuracy of King-Devick test speed (in second), with reverse reading direction having superior diagnostic accuracy to identify individuals with multiple concussion history compared to the use of conventional reading direction of the King-Devick test.
Within 10 years of last concussion
Study Arms (6)
No Concussion Conventional KD
SHAM COMPARATORParticipants without concussion history perform conventional King-Devick Test.
No Concussion Reverse KD
ACTIVE COMPARATORParticipants without concussion history perform reverse King-Devick Test.
Single Concussion Conventional KD
SHAM COMPARATORParticipants with 1 concussion history perform conventional King-Devick Test.
Single Concussion Reverse KD
ACTIVE COMPARATORParticipants with 1 concussion history perform reverse King-Devick Test.
Multiple Concussion Conventional KD
SHAM COMPARATORParticipants with 2 or more concussion history perform conventional King-Devick Test.
Multiple Concussion Reverse KD
ACTIVE COMPARATORParticipants with 2 or more concussion history perform reverse King-Devick Test.
Interventions
Conventional King-Devick test involves a series of number reading task from left to right and top to bottom, intending to test subjects' neuro-ophthalmologic function
Reverse King-Devick test involves a series of number reading task from right to left and bottom to top, intending to test subjects' neuro-ophthalmologic function
Eligibility Criteria
You may qualify if:
- between 18 and 26 years old,
- enrolled as an IU Bloomington student
- a fluent English speaker.
You may not qualify if:
- proficient fluency of any language that reads right to left (e.g. Arabic, Hebrew, Persian/ Farsi, Urdu Sindhi) or top to bottom and right to left (e.g. Japanese, Korean, or Chinese)
- a history of only one diagnosed concussion
- any visual, ocular, or brain injury within the past 12 months
- any history of an eye movement disorder
- any noncorrected visual impairment
- a diagnosis of attention deficit/hyperactivity disorder, attention deficit disorder, dyslexia, dyscalculia, or a language processing disorder.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Indiana University School of Public Health
Bloomington, Indiana, 47405, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
September 13, 2020
First Posted
September 23, 2020
Study Start
September 20, 2020
Primary Completion
May 1, 2022
Study Completion
May 1, 2022
Last Updated
February 23, 2023
Record last verified: 2023-02