NCT04558762

Brief Summary

The investigators intend to investigate the long-term complications and the subjective well-being among women who underwent insertion of a MUS due to stress urinary incontinence 2006-2010.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
15,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2020

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2020

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

September 4, 2020

Completed
18 days until next milestone

First Posted

Study publicly available on registry

September 22, 2020

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2021

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2022

Completed
Last Updated

September 22, 2020

Status Verified

September 1, 2020

Enrollment Period

1.1 years

First QC Date

September 4, 2020

Last Update Submit

September 15, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Stress urinary incontinence

    We will measure the percentage of women who suffer from a subjective feeling of stress urinary incontinence ten years after surgery. We will use validated scales; UDI-6 ( Urogenital Distress Inventory), IIQ-7 (Incontinence Impact Questionnaire).

    +10 years after surgery

Secondary Outcomes (5)

  • Number of participants with late post operative complications

    +10 years after surgery

  • Number of patients with pelvic pain

    +10 years after surgery

  • Number of participants with groin pain

    +10 years after surgery

  • Number of participants with dyspareunia

    +10 years after surgery

  • Number of participants that has had a reoperation

    Up to 14 years after first surgery

Study Arms (2)

Women who had a MUS inserted.

Women who underwent surgery with insertion of a MUS due to SUI 2006-2010 in Sweden with the MUS coming out retropubic (TVT) or through foramen obturatorium (TOT).

Controls

Women who have not had a MUS inserted due to stress urinary incontinence. Matched in age.

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Women who underwent MUS surgery in Sweden 2006-2010 due to stress urinary incontinence. The controlgroup will consist of women who did not undergo this surgery but are matched in age with the women who underwent surgery.

You may qualify if:

  • Underwent a MUS in Sweden 2006-2010 due to stress urinary incontinence.
  • Were registered in The Swedish National Quality Register of Gynecological Surgery.

You may not qualify if:

  • Did not undergo MUS surgery in Sweden 2006-2010 due to stress urinary incontinence, except those constituting the control group.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Obstetrics and Gynecology, Stockholm South General Hospital

Stockholm, 11883, Sweden

Location

MeSH Terms

Conditions

Urinary Incontinence, Stress

Condition Hierarchy (Ancestors)

Urinary IncontinenceUrination DisordersUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesLower Urinary Tract SymptomsUrological ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Marion Ek, MD, PhD

    Karolinska Institutet

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Senior Consultant

Study Record Dates

First Submitted

September 4, 2020

First Posted

September 22, 2020

Study Start

September 1, 2020

Primary Completion

October 1, 2021

Study Completion

October 1, 2022

Last Updated

September 22, 2020

Record last verified: 2020-09

Data Sharing

IPD Sharing
Will not share

Locations