Comparative Study Between Fat Injection And Platelet Rich Plasma In Post Burn Facial Scar

NCT04557514 | Unknown

• 1 other identifier: facial burn scar
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Best method in management of facial burn scar

Conditions

Burn Scar

Outcome Measures

Primary Outcomes (1)

• vancouver scale

  Pigmentation (0-2) Normal 0 Hypopigmentation 1 Hyperpigmentation 2 Vascularity (0-3) Normal 0 Pink 1 Red 2 Purple 3 Pliability (0-5) Normal 0 Supple 1 Yielding 2 Firm 3 Banding 4 Contracture 5 Height (0-3) Normal (flat) 0 0-2 mm 1 2-5 mm 2 \>5 mm 3

  3 months

Study Arms (2)

platelet rich plasma injection in post burn facial scar

ACTIVE COMPARATOR

prp in subgroup allocation 1:1 Obtain WB by venipuncture in acid citrate dextrose (ACD) tubes Do not chill the blood at any time before or during platelet separation. Centrifuge the blood using a 'soft' spin. Transfer the supernatant plasma containing platelets into another sterile tube (without anticoagulant). Centrifuge tube at a higher speed (a hard spin) to obtain a platelet concentrate. The lower 1/3rd is PRP and upper 2/3rd is platelet-poor plasma (PPP). At the bottom of the tube, platelet pellets are formed. Remove PPP and suspend the platelet pellets in a minimum quantity of plasma (2-4 mL) by gently shaking the tube.

Procedure: platelet rich plasma injection in post burn facial scar; Procedure: fat injection in post burn facial scar

fat injection in post burn facial scar

ACTIVE COMPARATOR

After aspiration of the fatty tissue, it is important that nonviable components of the aspirate, such as oil, blood, and local anesthetics are removed and, at the same time, the quality, integrity, and viability of the adipocytes and the inherent mesenchymal stem cells in the aspirate be maintained. Processing techniques are sedimentation , filtering and washing There is no consensus as to the optimal method of fat graft preparation.

Procedure: platelet rich plasma injection in post burn facial scar; Procedure: fat injection in post burn facial scar

Interventions

platelet rich plasma injection in post burn facial scar PROCEDURE

2 spins\>\>\> 1. st spin (separate plasma from blood) 2500 for 10 minutes 2. nd spin (separate platelet rich part of plasma) 1500 for 10 minutes Taking lower part (platelet rich plasma ) Injection under scar after rigotomy

fat injection in post burn facial scar; platelet rich plasma injection in post burn facial scar

fat injection in post burn facial scar PROCEDURE

Anesthesia : general or local Lipoaspirate from abdomen or thigh using adrenaline(1\\1000000) + ringer lactate + zylocaine Liposuction by canula no4 Sediment 3 layers : taking mid layer of fat and omit uppermost and lowermost layers Lipoinjection in fan shaped manner 10-20 cc according to site affected by canula no 1 .

fat injection in post burn facial scar; platelet rich plasma injection in post burn facial scar

Eligibility Criteria

• Age: 15 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Patients With Post Burn Facial Scar
• Age: 15 \_60 Yrs Old
• Mature Burn Scar (After 3 Months)

You may not qualify if:

• Patients Less Than 15 Yrs Old
• Patients More Than 60 Yrs Old
• Patients With Comorbidies (Hypertension-Diabetes-Thromboembolic Diseases-Immunocomprimized Patients)
• Patients With Burn Scar In Any Site Of Body Other Than Face

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Bhooshan LS, Devi MG, Aniraj R, Binod P, Lekshmi M. Autologous emulsified fat injection for rejuvenation of scars: A prospective observational study. Indian J Plast Surg. 2018 Jan-Apr;51(1):77-83. doi: 10.4103/ijps.IJPS_86_17.

  PMID: 29928084 BACKGROUND

• Ozcelik U, Ekici Y, Bircan HY, Aydogan C, Turkoglu S, Ozen O, Moray G, Haberal M. Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury. Med Sci Monit. 2016 Jun 5;22:1903-9. doi: 10.12659/msm.895395.

  PMID: 27262706 BACKGROUND

MeSH Terms

Interventions

CD36 Antigens

Intervention Hierarchy (Ancestors)

Platelet Membrane Glycoproteins; Membrane Glycoproteins; Glycoproteins; Glycoconjugates; Carbohydrates; Fatty Acid Transport Proteins; Membrane Transport Proteins; Carrier Proteins; Proteins; Amino Acids, Peptides, and Proteins; Membrane Proteins; Receptors, Cell Surface; Receptors, Immunologic; Scavenger Receptors, Class B; Receptors, Scavenger; Receptors, LDL; Receptors, Lipoprotein

Study Officials

• wagdi mohamed, lecturer

  lecturer

  STUDY DIRECTOR

Central Study Contacts

abdelrahman mostafa shehata, doctor

CONTACT

01020905498; abdelrahmanshehata084@gmail.com

youssef saleh, professor

CONTACT

01001166118; Yossef66@aun.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: official investigator

Study Record Dates

• First Submitted: September 14, 2020
• First Posted: September 21, 2020
• Study Start: October 1, 2020
• Primary Completion: October 1, 2023
• Study Completion: December 1, 2023
• Last Updated: September 21, 2020

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share