Prevention Interventions for Opioid Misuse
Optimized Interventions to Prevent Opioid Use Disorder Among Adolescents and Young Adults in the Emergency Department
2 other identifiers
interventional
1,155
1 country
1
Brief Summary
The purpose of the study is to develop and test innovative interventions to prevent the development of opioid misuse and opioid use disorders among older adolescents and young adults (AYA; ages 16-30) who use opioids, which will be initiated from a health care visit in the emergency department and extended post discharge via a telehealth approach. This study will have significant impact by identifying optimal, cost-effective opioid prevention strategies to sustain outcomes among AYAs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jan 2021
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 25, 2020
CompletedFirst Posted
Study publicly available on registry
September 16, 2020
CompletedStudy Start
First participant enrolled
January 4, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 14, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 14, 2025
CompletedResults Posted
Study results publicly available
August 3, 2026
CompletedAugust 25, 2026
August 1, 2026
4.3 years
August 25, 2020
March 27, 2026
August 3, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Opioid Misuse Severity Score (Past 3-month)
Alcohol Smoking and Substance Involvement Screening Test severity risk score (severity of prescription opioids/heroin consumption and consequences, scores range 0-27 per subscale; the prescription opioid and heroin subscales are summed such that total possible range on this measure is 0-54, higher score indicates worse outcomes/more severity). Note: missing data was imputed and median scores are presented.
3, 6, and 12 months
Secondary Outcomes (5)
Overdose Risk Behaviors
3, 6, and 12 months
Past 30-day Opioid Misuse (Dichotomized: 1+ Day vs. 0 Days)
3, 6, and 12 months
Other Drug and Alcohol Use Severity
3, 6, and 12 months
Substance Use Consequences
3, 6, and 12 months
Impaired Driving
3, 6, and 12 months
Study Arms (4)
Brief intervention (BI) then Portal
EXPERIMENTALThe BI will be delivered at intake and the portal will occur for 4 weeks starting at intake. All participants receive an opioid disposal bag at enrollment (in-person or mailed).
Brief intervention (BI) then Enhanced Usual Care (EUC)
EXPERIMENTALThe BI will be delivered at intake and EUC will be added 4 weeks later. All participants receive an opioid disposal bag at enrollment (in-person or mailed).
Enhanced Usual Care (EUC) then Portal
EXPERIMENTALEUC will be delivered at intake and the portal will occur for 4 weeks starting at intake. All participants receive an opioid disposal bag at enrollment (in-person or mailed).
Enhanced Usual Care (EUC) then EUC
ACTIVE COMPARATOREUC will be delivered at intake and delivered again 4 weeks later. All participants receive an opioid disposal bag at enrollment (in-person or mailed).
Interventions
A remote brief intervention delivered by health coaches that uses Motivational Interviewing to address opioid misuse and risk factors. Remote health coaches use a web-based clinician support guide to maintain fidelity, while tailoring the session to unique participant factors.
Remote health coaches will push tailored messages to participants over a 4-week period. The messages will use Motivational Interviewing strategies. The messages are designed to elicit a response from the participant. Health coaches will also respond to participant replies consistent with Motivational Interviewing over a course of 4 weeks.
The brochure covers educational topics like opioid storage and disposal and overdose prevention, as well as resources such as naloxone, suicide hotlines, mental health, and substance use treatment. It will be available online and in print.
Eligibility Criteria
You may qualify if:
- Aged 16-30 years
- Seeking care in Michigan Medicine emergency department (ED)
- Ability to read/comprehend and communicate in English
- Medically \& cognitively able to provide consent or assent
- Prescription opioid use plus \>=1 other risk factor (misuse positive for marijuana, other illicit drugs, other prescription drug misuse; binge drinking; depression or suicidality) or opioid misuse \[prescription opioid misuse or illicit opioid use (e.g., heroin, fentanyl)\]
You may not qualify if:
- Presenting with acute sexual assault, acute suicidality or a current cancer diagnosis/are currently receiving cancer treatment
- Current pregnancy at baseline
- History of injection drug use within last 12 months
- High risk for opioid use disorder
- Enrolled in Aim 1
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Michiganlead
- National Institute on Drug Abuse (NIDA)collaborator
Study Sites (1)
University of Michigan
Ann Arbor, Michigan, 48109, United States
Related Publications (3)
Kuklinski MR, Gibbons BJ, Bowser DM, McCollister KE, Smart R, Dunlap LJ, Shenkar E, Bonar EE, Boomer T, Campbell M, Fiellin LE, Hutton DW, Rao V, Saldana L, Su K, Walton MA, Yilmazer T. Investing in Interventions to Prevent Opioid Use Disorder in Adolescents and Young Adults: Start-up Costs from NIDA's HEAL Prevention Initiative. Prev Sci. 2025 Nov;26(7):1045-1055. doi: 10.1007/s11121-025-01835-6. Epub 2025 Oct 14.
PMID: 41085955DERIVEDSeewald L, Bonar E, Bohnert ASB, Carter PM, King CA, Losman ED, Bacon L, Wheeler T, Walton M. Lifetime non-fatal overdose experiences among at-risk adolescents and young adults in the emergency department with past-year opioid use in the USA. Inj Prev. 2024 Oct 1;30(5):373-380. doi: 10.1136/ip-2023-045072.
PMID: 38331586DERIVEDBonar EE, Kidwell KM, Bohnert ASB, Bourque CA, Carter PM, Clark SJ, Glantz MD, King CA, Losman ED, McCabe SE, Philyaw-Kotov ML, Prosser LA, Voepel-Lewis T, Zheng K, Walton MA. Optimizing scalable, technology-supported behavioral interventions to prevent opioid misuse among adolescents and young adults in the emergency department: A randomized controlled trial protocol. Contemp Clin Trials. 2021 Sep;108:106523. doi: 10.1016/j.cct.2021.106523. Epub 2021 Aug 2.
PMID: 34352386DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Maureen Walton
- Organization
- University of Michigan
Study Officials
- PRINCIPAL INVESTIGATOR
Maureen Walton, PhD
University of Michigan
- PRINCIPAL INVESTIGATOR
Erin Bonar, PhD
University of Michigan
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- CARE PROVIDER
- Purpose
- PREVENTION
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Psychiatry
Study Record Dates
First Submitted
August 25, 2020
First Posted
September 16, 2020
Study Start
January 4, 2021
Primary Completion
April 14, 2025
Study Completion
April 14, 2025
Last Updated
August 25, 2026
Results First Posted
August 3, 2026
Record last verified: 2026-08
Data Sharing
- IPD Sharing
- Will not share