NCT04546971

Brief Summary

This project will test the effects of a telehealth counseling program on reducing alcohol use and improving HIV viral control among people with HIV who drink heavily. In total, 600 heavy drinkers with HIV will be assigned to either (a) a single session of brief counseling on alcohol use or (b) brief counseling plus referral to a telehealth counseling program that includes multiple sessions of counseling by videoconferencing and text messaging support. To understand the effects of the program, participants' alcohol use, HIV outcomes, and health will be assessed over a 2-year period.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
600

participants targeted

Target at P75+ for not_applicable

Timeline
1mo left

Started Jun 2021

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 2, 2020

Completed
12 days until next milestone

First Posted

Study publicly available on registry

September 14, 2020

Completed
9 months until next milestone

Study Start

First participant enrolled

June 22, 2021

Completed
4.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 15, 2026

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 15, 2026

Expected
Last Updated

August 18, 2025

Status Verified

August 1, 2025

Enrollment Period

4.8 years

First QC Date

September 2, 2020

Last Update Submit

August 14, 2025

Conditions

Outcome Measures

Primary Outcomes (6)

  • Alcoholics drinks consumed per week

    Average number of alcoholic drinks consumed per week over the past 30 days

    12 months

  • Alcoholics drinks consumed per week

    Average number of alcoholic drinks consumed per week over the past 30 days

    24 months

  • Number of heavy drinking days

    Number of days consuming 4 or more drinks in a day over the past 30 days

    12 months

  • Number of heavy drinking days

    Number of days consuming 4 or more drinks in a day over the past 30 days

    24 months

  • Proportion of participants with a detectable HIV viral load

    Viral load test result that indicates HIV virus is detectable in the blood

    12 months

  • Proportion of participants with a detectable HIV viral load

    Viral load test result that indicates HIV virus is detectable in the blood

    24 months

Secondary Outcomes (6)

  • Proportion of the past 30 days adherent to antiretroviral therapy

    12 months

  • Proportion of the past 30 days adherent to antiretroviral therapy

    24 months

  • Condomless sex with non-steady partners

    12 months

  • Condomless sex with non-steady partners

    24 months

  • Veterans Aging Cohort Study (VACS) index total score

    12 months

  • +1 more secondary outcomes

Study Arms (2)

Brief intervention

ACTIVE COMPARATOR

A brief alcohol intervention lasting about 10 minutes, delivered after the baseline assessments.

Behavioral: Brief Intervention

Brief Intervention plus Telehealth Counseling

EXPERIMENTAL

A brief alcohol intervention followed by referral to a telehealth counseling protocol including 5 sessions of counseling based on Motivational Interviewing and delivered by videoconferencing. Telehealth counseling extends for up to two years and also includes a text messaging intervention to encourage reductions in drinking.

Behavioral: Brief InterventionBehavioral: Telehealth CounselingBehavioral: Text messaging

Interventions

Brief alcohol intervention delivered by telephone or videoconferencing focusing on advising participants to reduce drinking

Brief Intervention plus Telehealth CounselingBrief intervention

5 sessions of counseling on alcohol use based on Motivational Interviewing.

Brief Intervention plus Telehealth Counseling
Text messagingBEHAVIORAL

A daily and then monthly text messaging program designed to help participants monitor drinking, set goals, and reinforce successful reduction or abstinence.

Brief Intervention plus Telehealth Counseling

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • In care for HIV at one of 4 participating federally qualified health centers, report at least one heavy drinking day (4+ drinks) or average more than 7 drinks per week in the past 30 days

You may not qualify if:

  • need for supervised alcohol detoxification, as indicated by having a history of severe withdrawal symptoms such as seizures and delirium tremens.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Brown University

Providence, Rhode Island, 02912, United States

Location

MeSH Terms

Conditions

Alcohol Drinking

Interventions

Crisis Intervention

Condition Hierarchy (Ancestors)

Drinking BehaviorBehavior

Intervention Hierarchy (Ancestors)

PsychotherapyBehavioral Disciplines and Activities

Study Officials

  • Christopher Kahler, PhD

    Brown University School of Public Health

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 2, 2020

First Posted

September 14, 2020

Study Start

June 22, 2021

Primary Completion

April 15, 2026

Study Completion (Estimated)

May 15, 2026

Last Updated

August 18, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

Data will be shared through the National Data Archive. We also will post de-identified data used in the primary analyses of trial outcomes after those have been published.

Shared Documents
STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
Time Frame
Data in the NDA will be available 6 months after the first participants are recruited and will remain in there.
Access Criteria
Investigators can access date in the NDA using the available portal. We will allow access to the outcomes data to all through Brown's data archive once the outcome paper is published.

Locations