Predicting Metastatic Oral Squamous Cell Carcinomas With Molecular Biomarkers Using Machine Learning
1 other identifier
observational
500
1 country
1
Brief Summary
Application Management Team: PI - Siu Wai Choi; email - htswchoi@hku.hk Delegates - Chui Shan Chu; email: sunshine.c@connect.hku.hk FollowUpUsers - Chui Shan Chu; email:sunshine.c@connect.hku.hk
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2020
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 7, 2020
CompletedFirst Submitted
Initial submission to the registry
September 8, 2020
CompletedFirst Posted
Study publicly available on registry
September 10, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2023
CompletedSeptember 11, 2020
November 1, 2019
1.3 years
September 8, 2020
September 9, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The primary outcomes of the study are metastasis and recurrent disease
These outcomes will be entered as the dependent variables into the machine learning model
Baseline of OSCC
Study Arms (2)
Patients with Progressive Disease
Patients with metastasis and/or recurrent OSCC were considered as a group of subjects with progressive disease
Patients without Progressive Disease
Patients without metastasis and/or recurrent OSCC were considered as a group of subjects without progressive disease
Interventions
Resection of tumors
Eligibility Criteria
This is a retrospective, cohort study of all oral SCC patients who were treated with surgery for their primary oral SCC tumours at Queen Mary Hospital, from 1st October 2000 to 1st October 2019. The investigation will involve retrieval of paraffin embedded tissue blocks, determination of biomarker profile in these tissues, and retrieval of patient data from the Clinical Management System. No new patients will be prospectively recruited into the study.
You may qualify if:
- patients with oral squamous carcinoma
- received surgery from 1st October 2000 to 1st October 2019
You may not qualify if:
- N/A
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The University of Hong Kong
Hong Kong, Hong Kong
Biospecimen
Embedded blocks will be used for protein expressions
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Research Assistant Professor
Study Record Dates
First Submitted
September 8, 2020
First Posted
September 10, 2020
Study Start
September 7, 2020
Primary Completion
December 31, 2021
Study Completion
December 31, 2023
Last Updated
September 11, 2020
Record last verified: 2019-11