NCT04541238

Brief Summary

Magnetic resonance imaging (MRI) is the most used diagnostic tool for pre-operative assessment of anal fistula. However, there is lack of standardization in reporting this investigation. Moreover, reports may miss a number of key information for surgical planning. The aim of this study is to assess the effectiveness, reproducibility, and acceptability of a new template for reporting anal fistula, which may favor standardization in clinical practice and inform surgical decision making.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Sep 2020

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 1, 2020

Completed
Same day until next milestone

Study Start

First participant enrolled

September 1, 2020

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 9, 2020

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2020

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2021

Completed
Last Updated

September 9, 2020

Status Verified

September 1, 2020

Enrollment Period

4 months

First QC Date

September 1, 2020

Last Update Submit

September 1, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Effectiveness of the novel template compared to standard reporting based on the number of key descriptors

    60 days

Secondary Outcomes (2)

  • Inter-rater agreement between two independent experienced radiologists using the novel template

    7 days

  • Qualitative analysis

    30 days

Study Arms (1)

Novel template report

The last 100 consecutive and anonymized MRI investigations for primary perianal fistula reported according to standard practice by dedicated radiologists (the last 10 reports from each of 10 international centers) are reviewed blindly and independently by two experienced radiologists (based on case load, years of experience and publications on anal fistula) using a novel template incorporating 8 key descriptors. A third independent experienced radiologist will resolve any disagreement and assess the presence of descriptors in the original report compared to the novel template.

Diagnostic Test: MRI

Interventions

MRIDIAGNOSTIC_TEST

Magnetic resonance imaging

Novel template report

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

100 MRI investigations for anal fistula.

You may qualify if:

  • Adults with primary anal fistula (cryptoglandular or Crohn-related) undergoing MRI

You may not qualify if:

  • Active cancer of the anorectum
  • Recto-vaginal fistula

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Treviso Regional Hospital

Treviso, Italy

Location

Related Publications (1)

  • Sudol-Szopinska I, Santoro GA, Kolodziejczak M, Wiaczek A, Grossi U. Magnetic resonance imaging template to standardize reporting of anal fistulas. Tech Coloproctol. 2021 Mar;25(3):333-337. doi: 10.1007/s10151-020-02384-6. Epub 2021 Jan 5.

MeSH Terms

Conditions

Rectal Fistula

Condition Hierarchy (Ancestors)

Intestinal FistulaDigestive System FistulaDigestive System DiseasesIntestinal DiseasesGastrointestinal DiseasesRectal DiseasesFistulaPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Officials

  • Ugo Grossi, PhD

    Treviso Regional Hospital, University of Padua

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
NETWORK
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Colorectal Surgeon

Study Record Dates

First Submitted

September 1, 2020

First Posted

September 9, 2020

Study Start

September 1, 2020

Primary Completion

December 31, 2020

Study Completion

January 31, 2021

Last Updated

September 9, 2020

Record last verified: 2020-09

Data Sharing

IPD Sharing
Will share

IPD are available on request

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR

Locations