Efficiency of Combined Rehabilitation Programs Including Resistance and Endurance Exercises on Functional Capacities, Quality of Life and Daily Level of Activities in Hemodialysis Patients

NCT04538248 | Completed

• 1 other identifier: RECHMPL20_0403
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Hemodialysis patients display among the lowest level of daily activities and decline of functional abilities is highly correlated with mortality. Perdialytic exercise during hemodialysis procedure is now part of the patients' routine care and appears to be a solution to struggle against the functional skills decrease. Our team was able to demonstrate that beyond muscle mass, muscle strength and physical activity were essential determinants of morbidity and mortality of dialysis patients. The AIDER Santé medical team has set up an assessment of physical activities and muscle strength in the Montpellier and Nimes centers. In order to rehabilitate muscle strength and endurance, perdialytic exercise may be prescribed. Its effectiveness can be appreciated by measuring the SPPB score (Short Physical Performance Battery). Recent studies established that combined training including resistance and endurance exercises was the most effective to improve functional performance. In AIDER Santé dialysis centers, the two mainly used exercise approaches are distinguished by the time distribution of the two types of exercise: the first plans to practice both types of exercise at each session (continuous program), the second plans to alternate a week of resistance exercise with a week of endurance exercise (discontinuous program). It is established that the rehabilitation of the hemodialysis patient must include both resistance and endurance exercises, but the combination of these exercises during the same session is potentially at the origin of an interference phenomenon, limiting neuromuscular adaptations specific to each effort. Therefore, the main hypothesis of the project is that the temporal separation of resistance and endurance exercises in a discontinuous program could optimize the functional gains of combined rehabilitation and therefore be more effective than a continuous program generating a phenomenon of interference.

Conditions

Chronic Kidney Diseases; Hemodialysis; Physical Rehabilitation

Keywords

Perdialytic exercise; Combined rehabilitation; Functional abilities; Interference effect

Outcome Measures

Primary Outcomes (1)

• Short Physical

  Short Physical Performance Battery Score

  Week 0, week 17

Secondary Outcomes (1)

• Knee extension force

  1 day

Study Arms (2)

Continuous

Continuous

Other: Combined rehabilitation during hemodialysis

Discontinuous

Discontinuous

Other: Combined rehabilitation during hemodialysis

Interventions

Combined rehabilitation during hemodialysis OTHER

Combined rehabilitation during hemodialysis

Continuous; Discontinuous

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hemodialysis patients of Montpellier AIDER Santé dialysis center

You may qualify if:

• Hemodialysis started since at least 3 months
• Medical prescription of perdialytic combined exercise
• Age \< 85
• Life expectancy \> 6 months

You may not qualify if:

• Ischemic and valvular cardiopathies
• Lower-extremity arterial disease (stade III and IV)
• Knee or hip amputation/prothesis
• Severe respiratory disease
• BMI \> 35
• Pacemaker

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uhmontpellier

Montpellier, 34290, France

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jean-Paul CRISTOL, Prof

  CHU Lapeyronie, Department of Biochemistry and Hormonology, Montpellier, FRANCE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 2, 2020
• First Posted: September 4, 2020
• Study Start: August 1, 2020
• Primary Completion: December 1, 2020
• Study Completion: March 1, 2021
• Last Updated: March 18, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)