Cardiovascular Responses to Heat Waves in the Elderly
Heat Waves in the Elderly: Reducing Thermal and Cardiovascular Consequences
2 other identifiers
interventional
59
1 country
1
Brief Summary
The purpose of this study is to assess the cardiovascular responses of the elderly to heat wave conditions
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2021
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 28, 2020
CompletedFirst Posted
Study publicly available on registry
September 3, 2020
CompletedStudy Start
First participant enrolled
January 19, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 20, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
February 20, 2023
CompletedResults Posted
Study results publicly available
August 7, 2025
CompletedOctober 23, 2025
October 1, 2025
2.1 years
August 28, 2020
June 25, 2025
October 21, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in Core Body Temperature
Core body temperature will be measured via a telemetric pill or rectal temperature probe.
Prior to and after the 3-hour simulated heat wave exposure.
Change in Peak Mitral Annular Systolic Velocity (S')
Change in peak mitral annular systolic velocity was measured by tissue doppler imaging.
Prior to, during, and after each simulated heat wave exposure; approximately 20 min each
Secondary Outcomes (4)
Ending Skin Temperature
At the end of the 3-hour simulated heat wave exposure.
Ending Heart Rate
At the end of the 3-hour simulated heat wave exposure.
Ending Mean Arterial Pressure
At the end of the 3-hour simulated heat wave exposure.
Change in Cardiac Output
Prior to and after the 3-hour simulated heat wave exposure.
Study Arms (4)
Younger participants: Hot/Dry then Hot/Humid
OTHERIndividuals aged 18-39 years who completed the hot/dry trial first and the hot/humid trial second.
Older participants: Hot/Dry then Hot/Humid
OTHERIndividuals aged 65 years or older who completed the hot/dry trial first and the hot/humid trial second.
Younger participants: Hot/Humid then Hot/Dry
OTHERIndividuals aged 18-39 years who completed the hot/humid trial first and the hot/dry trial second.
Older participants: Hot/Humid then Hot/Dry
OTHERIndividuals aged 65 years or older who completed the hot/humid trial first and the hot/dry trial second.
Interventions
Individuals will be exposed to a simulated heat wave (hot and humid) condition.
Individuals will be exposed to a simulated heat wave (hot and dry) condition.
Eligibility Criteria
You may qualify if:
- Healthy male and female individuals
- years or 65+ years of age
- Free of any underlying moderate to serious medical conditions
You may not qualify if:
- Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia.
- Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses.
- Abnormalities detected on routine screening.
- Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
- Current smokers, as well as individuals who regularly smoked within the past 3 years.
- Body mass index of greater than 30 kg/m\^2
- Pregnant individuals
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Texas Southwestern Medical Centerlead
- American Heart Associationcollaborator
- National Institute on Aging (NIA)collaborator
Study Sites (1)
Institute for Exercise and Environmental Medicine
Dallas, Texas, 75231, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Craig Crandall
- Organization
- Institute for Exercise and Environmental Medicine
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Medicine
Study Record Dates
First Submitted
August 28, 2020
First Posted
September 3, 2020
Study Start
January 19, 2021
Primary Completion
February 20, 2023
Study Completion
February 20, 2023
Last Updated
October 23, 2025
Results First Posted
August 7, 2025
Record last verified: 2025-10