NCT04537845

Brief Summary

Cancer pain deteriorated in quality of life and related with numerous psychosocial problems. Over the one third of cancer patient suffered from moderate to severe cancer pain, even under adequate pain management. The 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images can provide quantitative results in clinical oncology. As a functional neuroimaging, the PET evidently provided anatomical activated regions, size, and spatial extent information. In this retrospective study, we use FDG-PET to investigate changes concerning the glucose metabolism in the brain with or without cancer pain.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
119

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Mar 2020

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 2, 2020

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 8, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 8, 2020

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

August 30, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 3, 2020

Completed
Last Updated

September 21, 2022

Status Verified

August 1, 2021

Enrollment Period

5 months

First QC Date

August 30, 2020

Last Update Submit

September 19, 2022

Conditions

Cancer Pain

Outcome Measures

Primary Outcomes (1)

  • Find the location of brain metabolic changes, pain scale

    This retrospective analysis only compare image and clinical record including pain scale

    12 months

Study Arms (2)

with cancer pain

without cancer pain

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

cancer patient with or without cancer pain

You may qualify if:

  • cancer patient

You may not qualify if:

  • no brain metastasis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan University Hosipital

Taipei, 100, Taiwan

Location

Related Publications (1)

  • Lin WY, Hsieh JC, Lu CC, Ono Y. Altered metabolic connectivity between the amygdala and default mode network is related to pain perception in patients with cancer. Sci Rep. 2022 Aug 18;12(1):14105. doi: 10.1038/s41598-022-18430-2.

    PMID: 35982228DERIVED

MeSH Terms

Conditions

Cancer Pain

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Wen-ying Lin

    National Taiwan University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 30, 2020

First Posted

September 3, 2020

Study Start

March 2, 2020

Primary Completion

August 8, 2020

Study Completion

August 8, 2020

Last Updated

September 21, 2022

Record last verified: 2021-08

Locations

TW(1)