Impact of COVID-19 Outbreak on Non-COVID-19 Patients

NCT04537559 | Unknown

• 1 other identifier: 2020-01017
• Study Type: observational
• Target: 240,000
• Locations: 1 country
• Sites: 1

Brief Summary

The Geneva Canton organized the health crisis of the COVID-19 epidemic around the care of COVID patients at the University Hospital (HUG), by moving the care of non-COVID patients to private hospitals of the canton. The COVID epidemic appears to have been associated with a decrease in consultations and care for non-COVID patients. An excess of morbidity and mortality (non-COVID) would be possible during or after the epidemic in connection with this "under-medicalization" of non-COVID patients. The aim of this study is to measure and analyze the impact on the morbidity and mortality of inpatients during and after the COVID-19 epidemic in the adult inpatient wards of HUG and township hospitals / clinics.

Conditions

COVID-19

Keywords

COVID-19 Outbreak; non COVID-19

Outcome Measures

Primary Outcomes (2)

• Intra-hospital mortality

  death during hospitalization of each patient

  Assessed at the discharge date, up to 3 months after admission

• composite outcome (worsening during hospitalization)

  intra-hospital mortality and / or transfer to intensive care and / or transfer to intermediate care during hospitalization

  At the discharge date of hospitalization, up to 3 months after admission

Secondary Outcomes (66)

• Pathologies leading to hospitalization

  At the discharge date of hospitalization, up to 3 months after admission

• overall mortality at 3 months (90 days)

  within the 3 months after the admission date

• Potentially avoidable readmission rate

  During the 30 days after the patient's discharge

• mortality rate by pathology at 3 months

  within the 3 months after the admission date

• length of stay

  At the discharge date of hospitalization, up to 3 months after admission

Study Arms (3)

pre-COVID-19 period

Patients hospitalized between 1.3.2019 and 28.02.2020

per-COVID-19 period

Patients hospitalized between 1.3.2020 and 28.02.2022

post-COVID-19 period

Patients hospitalized between 1.3.2022 and 28.02.2023

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients hospitalized in Geneva hospital or clinic from the 1st march 2019 to 28 february 2023.

You may qualify if:

• Patient hospitalized in an adult department
• During the pre-period-COVID-19 period, the per-COVID-19 or the post-COVID-19 periods ie from the 1st march 2019 to 28 february 2023.

You may not qualify if:

• Patients who have been hospitalized for COVID-19 infection
• Patients hospitalized in the Department of Adolescent Woman and Child, Department of Psychiatry or Intensive Care Department during the same periods.

Sponsors & Collaborators

• University Hospital, Geneva: lead
• La Tour Hospital: collaborator

Study Sites (1)

Geneva University Hospital

Geneva, Canton of Geneva, 1255, Switzerland

Location

Related Publications (5)

• Welt FGP, Shah PB, Aronow HD, Bortnick AE, Henry TD, Sherwood MW, Young MN, Davidson LJ, Kadavath S, Mahmud E, Kirtane AJ; American College of Cardiology's Interventional Council and the Society for Cardiovascular Angiography and Interventions. Catheterization Laboratory Considerations During the Coronavirus (COVID-19) Pandemic: From the ACC's Interventional Council and SCAI. J Am Coll Cardiol. 2020 May 12;75(18):2372-2375. doi: 10.1016/j.jacc.2020.03.021. Epub 2020 Mar 19. No abstract available.

  PMID: 32199938 BACKGROUND

• Garcia S, Albaghdadi MS, Meraj PM, Schmidt C, Garberich R, Jaffer FA, Dixon S, Rade JJ, Tannenbaum M, Chambers J, Huang PP, Henry TD. Reduction in ST-Segment Elevation Cardiac Catheterization Laboratory Activations in the United States During COVID-19 Pandemic. J Am Coll Cardiol. 2020 Jun 9;75(22):2871-2872. doi: 10.1016/j.jacc.2020.04.011. Epub 2020 Apr 10. No abstract available.

  PMID: 32283124 BACKGROUND

• Roffi M, Guagliumi G, Ibanez B. The Obstacle Course of Reperfusion for ST-Segment-Elevation Myocardial Infarction in the COVID-19 Pandemic. Circulation. 2020 Jun 16;141(24):1951-1953. doi: 10.1161/CIRCULATIONAHA.120.047523. Epub 2020 Apr 21. No abstract available.

  PMID: 32315205 BACKGROUND

• Rosenbaum L. The Untold Toll - The Pandemic's Effects on Patients without Covid-19. N Engl J Med. 2020 Jun 11;382(24):2368-2371. doi: 10.1056/NEJMms2009984. Epub 2020 Apr 17. No abstract available.

  PMID: 32302076 BACKGROUND

• Killip T 3rd, Kimball JT. Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients. Am J Cardiol. 1967 Oct;20(4):457-64. doi: 10.1016/0002-9149(67)90023-9. No abstract available.

  PMID: 6059183 BACKGROUND

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Jerome Stirnemann, MD

  University Hospital, Geneva

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: August 27, 2020
• First Posted: September 3, 2020
• Study Start: March 1, 2019
• Primary Completion: February 28, 2022
• Study Completion: February 28, 2023
• Last Updated: March 25, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)