Risk Factors for Stress-induced Alcohol Misuse: Genetic Predictors and Mediation by Personality Type

NCT04533802 | Completed

• 1 other identifier: PHT/2019/63
• Study Type: observational
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

To examine whether variation in 'risk-taking' personality and linked genetic variants predicts susceptibility to, and resilience against, stress-induced alcohol misuse.

Conditions

Alcohol Use, Unspecified

Outcome Measures

Primary Outcomes (6)

• Alcohol misuse

  Measured using the alcohol use disorders identification test (AUDIT) (higher the score the worse the outcome)

  immediately after the procedure

• Recent stressors

  Measured using the 30 item Stress Overload Scale questionnaire (higher the score, the worse the outcome)

  Immediately after the study visit

• Life Events

  Measured using the Life Events Checklist Questionnaire (the higher the score the worse the outcome)

  Immediately after the study visit

• Impulse Behaviour

  Measured using the the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-P) higher values indicate more impulsive behavior.

  Immediately after the study visit

• Risk taking behaviour

  Measured by the Stop Signal Reaction Time Task (computer task) which measures the ability to inhibit a planned response

  Immediately after the study visit

• Molecular Anaylsis

  Cheek swabs will be taken from all participant to carry out genomic DNA analysis

  Immediately after the study visit

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be patients attending Portsmouth Hospitals University Trust following alcohol-related illness/injury and an AUDIT score of greater than 15 (suggesting high risk of dependence and alcohol misuse). They will be adults (\>18 years).

You may qualify if:

• Male or Female, aged (min) 18 years
• Attended Portsmouth Hospitals University Trust following illness/injury related to alcohol use
• Has a maximum AUDIT score of 15
• Is willing and able to comply with study procedures
• Willing and able to give informed consent for participation in the study.
• Must be recruited within 24 hrs of ASNS referral, and able to be tested within 48 hours of referral

You may not qualify if:

• ny reported/suspected intellectual/learning disabilities (e.g., Down's Syndrome), neurodevelopmental disorders (e.g., Autism, Asperger's) or acquired brain injury
• Has previously participated in this study
• Should not be under the influence of alcohol during the study (12hrs previous to taking part) - to be determined via breathalyser.
• Any history of advanced liver disease (clinical diagnosis of cirrhosis, jaundice, encephalopathy, ascites, variceal haemorrhage)

Sponsors & Collaborators

• Portsmouth Hospitals NHS Trust: lead
• University of Portsmouth: collaborator

Study Sites (1)

Portsmouth University Hospital

Portsmouth, Hampshire, PO63LY, United Kingdom

Location

MeSH Terms

Conditions

Alcohol Drinking

Condition Hierarchy (Ancestors)

Drinking Behavior; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 26, 2020
• First Posted: September 1, 2020
• Study Start: August 26, 2020
• Primary Completion: September 30, 2022
• Study Completion: September 30, 2022
• Last Updated: April 3, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)