Risk Factors for Stress-induced Alcohol Misuse: Genetic Predictors and Mediation by Personality Type
RISK
Personality and Genotypic Markers That Predict Individual Differences in Susceptibility to Stress-induced Alcohol Misuse: a Feasibility Study.
RISK
Personality and Genotypic Markers That Predict Individual Differences in Susceptibility to Stress-induced Alcohol Misuse: a Feasibility Study.
Sponsor study identifier
observational
29
1 country
1
Study Start
August 26, 2020
Actual (reported)Primary Completion
September 30, 2022
Actual (reported)Study Completion
September 30, 2022
Actual (reported)To examine whether variation in 'risk-taking' personality and linked genetic variants predicts susceptibility to, and resilience against, stress-induced alcohol misuse.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 30, 2022
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 26, 2020
Actual (reported)August 26, 2020
Actual (reported)September 1, 2020
Actual (reported)September 30, 2022
Actual (reported)September 30, 2022
Actual (reported)Alcohol misuse
Measured using the alcohol use disorders identification test (AUDIT) (higher the score the worse the outcome)
immediately after the procedure
Recent stressors
Measured using the 30 item Stress Overload Scale questionnaire (higher the score, the worse the outcome)
Immediately after the study visit
Life Events
Measured using the Life Events Checklist Questionnaire (the higher the score the worse the outcome)
Immediately after the study visit
Impulse Behaviour
Measured using the the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-P) higher values indicate more impulsive behavior.
Immediately after the study visit
Risk taking behaviour
Measured by the Stop Signal Reaction Time Task (computer task) which measures the ability to inhibit a planned response
Immediately after the study visit
Molecular Anaylsis
Cheek swabs will be taken from all participant to carry out genomic DNA analysis
Immediately after the study visit
Participants will be patients attending Portsmouth Hospitals University Trust following alcohol-related illness/injury and an AUDIT score of greater than 15 (suggesting high risk of dependence and alcohol misuse). They will be adults (\>18 years).
Portsmouth University Hospital
Portsmouth, Hampshire, PO63LY, United Kingdom
29 participants (actual enrollment reported by the registry).
First Submitted
August 26, 2020
First Posted
September 1, 2020
Study Start
August 26, 2020
Actual (reported)Personalized Feedback Programs for College Students
Contact the study team to confirm eligibility.
Primary Completion
September 30, 2022
Actual (reported)Study Completion
September 30, 2022
Actual (reported)Last Updated
April 3, 2023
Record last verified: 2023-01
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Source: ClinicalTrials.gov.
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