The Research About Acute Compartment Syndrome
Acute Compartment Syndrome
1 other identifier
observational
80
1 country
1
Brief Summary
Acute compartment syndrome (ACS) is defined as a clinical entity originated from trauma or other conditions, and remains challenging to diagnose and treat effectively. Threre is the controversy in diagnosing, treating ACS. It was found that there was no criterion about the ACS, and result unnecessary osteotomy. The presence of clinical assessment (5P) always means the necrosis of muscles and was the most serious or irreversible stage of ACS. Besides pressure methods, the threshold of pressure identifying ACS was also controversial.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2019
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2019
CompletedFirst Submitted
Initial submission to the registry
August 19, 2020
CompletedFirst Posted
Study publicly available on registry
August 27, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 9, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2030
ExpectedAugust 4, 2021
July 1, 2021
3.7 years
August 19, 2020
July 28, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (9)
injury mechanism
The relative data was collected about injury mechanism such as high falling accident, traffic accident, fall from standing height,Crushing
up to 1 weeks
the time when the blister appeared
The relative data was collected about the time when the blister appeared after injury
up to 4 weeks
time to reconstructive surgery
The relative data was collected about time to reconstructive surgery
time to when the surgery was conducted after 2 weeks
union time
The relative data was collected about union time
through study completion, an average of 1 year
No non-anatomic gap or step (larger than 5 mm)
The relative data was collected about complications
through study completion, an average of 1 year
secondary loss of reduction
The relative data was collected about complications
through study completion, an average of 1 year
Deep venous thrombosis
The relative data was collected about complications
through study completion, an average of 1 year
superficial wound problems
The relative data was collected about complications
through study completion, an average of 1 year
blister skin immunochemistry and immunofluorescence analysis
CK1, 5, 10, claudin 1, 2 and occludin as determined by immunochemistry analysis, and skin barrier proteins; claudin 1, 2 and occludin was determined by immunofluorescence analysis and qPCR.
through study completion, an average of 1 year
Secondary Outcomes (3)
CK levels
through hospitalization completion, an average of 1 month
chloride levels
through hospitalization completion, an average of 1 month
UREA levels
through hospitalization completion, an average of 1 month
Other Outcomes (2)
LKS score
through study completion, an average of 1 year
VAS scores
through study completion, an average of 1 year
Study Arms (2)
fractures with blister appeared
tibial plateau fractures with blister observed
fractures without blister appeared
tibial plateau fractures without blister observed
Interventions
if it was suspected with ACS, the fasciotomy was conducted. but if the blister observed, it means decreased conmpartment sydrome. therefore, the blister observed can avoid unnecessary fasciotomy to patients suspected with ACS
Eligibility Criteria
The severe tibial plateau (Ⅴand Ⅵ according to Schatzker's classification) in our hospital who will be treated with open internal fixation in our hospital
You may qualify if:
- Fracture patients with Schatzker V and VI,
- Who were older than eighteen years.
You may not qualify if:
- Patients who was eighteen years or younger.
- Patients treated with other implant,
- underwent conservative management were also excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
the Third Hospital of Hebei Medical University
Shijiazhuang, Hebei, 050000, China
Related Publications (2)
Guo J, Yin Y, Jin L, Zhang R, Hou Z, Zhang Y. Acute compartment syndrome: Cause, diagnosis, and new viewpoint. Medicine (Baltimore). 2019 Jul;98(27):e16260. doi: 10.1097/MD.0000000000016260.
PMID: 31277147BACKGROUNDWang T, Yang S, Guo J, Long Y, Hou Z. Predictors of muscle necrosis in patients with acute compartment syndrome. Int Orthop. 2023 Apr;47(4):905-913. doi: 10.1007/s00264-023-05699-9. Epub 2023 Jan 30.
PMID: 36715712DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Hou Zhiyong, Doctor
Hebei Medical University Third Hospital
Central Study Contacts
Ma Lijie, Doctor
CONTACT
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 19, 2020
First Posted
August 27, 2020
Study Start
January 1, 2019
Primary Completion
September 9, 2022
Study Completion (Estimated)
December 31, 2030
Last Updated
August 4, 2021
Record last verified: 2021-07
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL
- Time Frame
- 2 years after the experiment was conducted
- Access Criteria
- all authors focusing on ACS research
acute compartment syndrome