Case Fatalities in Hospitalised COVID-19 Patients in the UK
1 other identifier
observational
70,000
1 country
1
Brief Summary
This study will investigate how the case fatality in hospitalised patients with COVID-19 has changed throughout the pandemic. It will also explore possible mechanisms that could be driving these changes. This analysis will enhance our understanding of the virus, which will be important for researchers and clinicians to respond appropriately.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 24, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 2, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
August 2, 2020
CompletedFirst Submitted
Initial submission to the registry
August 24, 2020
CompletedFirst Posted
Study publicly available on registry
August 26, 2020
CompletedAugust 26, 2020
August 1, 2020
5 months
August 24, 2020
August 24, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Case fatality
The proportion of new admissions with COVID-19 who died over time
23 weeks
Study Arms (2)
Hospitalisations
All hospitalised COVID patients
Critical care
All hospitalised COVID patients in critical care
Interventions
Triage criteria for treating COVID-19 patients
Eligibility Criteria
All patients with proven or high likelihood of COVID-19 admitted to the 260 UK hospitals enrolled in the ISARIC-4C study
You may qualify if:
- All patients admitted with a proven or high likelihood of COVID-19
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Edinburgh
Edinburgh, United Kingdom
Related Publications (1)
Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJ, Baillie JK, Semple MG; ISARIC4C investigators. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020 May 22;369:m1985. doi: 10.1136/bmj.m1985.
PMID: 32444460BACKGROUND
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Annemarie B Docherty
Usher Institute, University of Edinburgh
- PRINCIPAL INVESTIGATOR
Ewen M Harrison
Usher Institute, University of Edinburgh
- PRINCIPAL INVESTIGATOR
Rachel H Mulholland
Usher Institute, University of Edinburgh
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 24, 2020
First Posted
August 26, 2020
Study Start
February 24, 2020
Primary Completion
August 2, 2020
Study Completion
August 2, 2020
Last Updated
August 26, 2020
Record last verified: 2020-08
Data Sharing
- IPD Sharing
- Will share
Access to all data and samples collected by ISARIC4C are controlled by an Independent Data and Materials Access Committee (IDAMAC), composed of representatives of research funders, academia, clinical medicine, public health and industry. Their job is to ensure that all data and samples are used to generate the greatest possible benefit to humanity, in the shortest possible time.