IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry

NCT04520347 | Enrolling By Invitation

• 1 other identifier: 17-001725
• Study Type: observational
• Target: 10,000
• Locations: 7 countries
• Sites: 41

Brief Summary

This is a prospective multi-center international registry. The objective of this registry is to collect prospective data on patients undergoing catheter ablation for Ventricular Tachycardia (VT) and Premature Ventricular Contractions (PVC). The registry will be used for clinical monitoring, research, and quality improvement purposes.

Conditions

Ventricular Arrhythmia; Ventricular Tachycardia; Cardiomyopathy; Premature Ventricular Contraction (PVC)

Keywords

Arrhythmia; Cardiac Conduction System Disease; Sudden Cardiac Death; Implantable Cardiac Defibrillator (ICD)

Outcome Measures

Primary Outcomes (1)

• Ventricular tachycardia (VT) recurrence

  Freedom from ventricular tachycardia episodes requiring ICD Intervention (shock or Anti-Tachycardia Pacing) or repeat procedure.

  From date of procedure assessed by shock, Anti-Tachycardia Pacing, or repeat procedure, up to 10 years.

Secondary Outcomes (2)

• Rate of complications

  From date of procedure assessed up to 12 months.

• Time to transplant or death

  From date of procedure assessed by date of transplant and/or death, up to 10 years.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with ventricular arrhythmias that undergo catheter ablation for ventricular tachycardia or premature ventricular contractions.

You may qualify if:

• \- All patients undergoing catheter ablation for ventricular tachycardia (VT) or premature ventricular contractions (PVCs).

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (41)

Banner Health, University of Arizona Medical Center

Phoenix, Arizona, 85719, United States

Location

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

Location

University of California, Los Angeles

Los Angeles, California, 90095, United States

Location

University of California, Davis

Sacramento, California, 95817, United States

Location

University of California San Francisco

San Francisco, California, 94143, United States

Location

University of Colorado Hospital

Aurora, Colorado, 80045, United States

Location

Hartford HealthCare

Hartford, Connecticut, 06103, United States

Location

University of Florida Health

Gainesville, Florida, 32610, United States

Location

The Kansas City Heart Rhythm Institute

Kansas City, Kansas, 66211, United States

Location

University of Maryland Medical Center

Baltimore, Maryland, 21201, United States

Location

Johns Hopkins Heart and Vascular Institute

Baltimore, Maryland, 21287, United States

Location

Boston Children's Hospital

Boston, Massachusetts, 02115, United States

Location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

UMass Memorial Health Care

Worcester, Massachusetts, 01655, United States

Location

University of Michigan Frankel Cardiovascular Center

Ann Arbor, Michigan, 48109, United States

Location

University of Minnesota VA Medical Center

Minneapolis, Minnesota, 55417, United States

Location

Mayo Clinic

Rochester, Minnesota, 55902, United States

Location

Washington University in St. Louis

St Louis, Missouri, 63130, United States

Location

The Mount Sinai Hospital

New York, New York, 10029, United States

Location

Columbia University Irving Medical Center

New York, New York, 10032, United States

Location

Montefiore Medical Center

The Bronx, New York, 10461, United States

Location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

Oregon Health & Science University

Portland, Oregon, 97239, United States

Location

Children's Hospital of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

University of Pennsylvania Health System

Philadelphia, Pennsylvania, 19104, United States

Location

Wellspan Health

York, Pennsylvania, 17403, United States

Location

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Location

Vanderbilt Heart and Vascular Institute

Nashville, Tennessee, 37232, United States

Location

Texas Cardiac Arrhythmia Institute at St. David's Medical Center

Austin, Texas, 78705, United States

Location

Houston Methodist Hospital

Houston, Texas, 77030, United States

Location

University of Utah Health

Salt Lake City, Utah, 84132, United States

Location

University of Virginia Health System

Charlottesville, Virginia, 22903, United States

Location

University of Washington Medical Center

Seattle, Washington, 98195, United States

Location

The Montreal Heart Institute

Montreal, Canada

Location

Shaare Zedek Medical Center

Jerusalem, Israel

Location

Dokkyo Medical University Koshigaya Hospital

Koshigaya, Japan

Location

Leiden University

Leiden, Netherlands

Location

Erasmus Medical Center

Rotterdam, Netherlands

Location

Gregorio Marañón General University Hospital

Madrid, Spain

Location

St. George's Hospital

Wandsworth, United Kingdom

Location

MeSH Terms

Conditions

Tachycardia, Ventricular; Ventricular Premature Complexes; Cardiomyopathies; Arrhythmias, Cardiac; Cardiac Conduction System Disease; Death, Sudden, Cardiac

Condition Hierarchy (Ancestors)

Tachycardia; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cardiac Complexes, Premature; Heart Arrest; Death, Sudden; Death

Study Officials

• Jason Bradfield, MD

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

• Kalyanam Shivkumar, MD, PhD

  University of California, Los Angeles

  STUDY CHAIR

• Paolo Della Bella, MD

  San Raffaele Hospital, Italy

  STUDY CHAIR

• Francis Marchlinski, MD, FACC, FAHA, FHRS

  University of Pennsylvania Health System

  STUDY CHAIR

• Andrea Natale, MD, FACC, FHRS, FESC

  Texas Cardiac Arrhythmia Institute at St. David's Medical Center

  STUDY CHAIR

• William G Stevenson, MD

  Vanderbilt Heart and Vascular Institute

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Specialized Program for Ventricular Tachycardia

Study Record Dates

• First Submitted: July 10, 2020
• First Posted: August 20, 2020
• Study Start: December 1, 2018
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): November 1, 2027
• Last Updated: December 15, 2025

Record last verified: 2025-12

Locations

US (34); JP (1); IL (1); NL (2); GB (1); ES (1); CA (1)