Screening Microorganism of Cryptogenic Mechanical Pneumonia Through Next Generation Sequencing to Lung Tissue Fluid

NCT04511884 | Unknown

• 1 other identifier: 2020040695
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 2

Brief Summary

The etiology of cryptogenic organizing pneumonia (COP)was not clear, but previous studies have shown that in some patients, some pathogen could be detected in bronchoalveolar lavage fluid (BALF), and may be one of the causes of COP. This study aimed to screen the pathogenic microorganisms in BALF and lung puncture fluid of the patients with COP through the next-generation sequencing to further clarify the correlation between the incidence of COP and pathogenic microorganisms.

Conditions

Cryptogenic Organizing Pneumonia; Idiopathic Interstitial Pneumonias

Keywords

cryptogenic organizing pneumonia; next-generation sequencing

Outcome Measures

Primary Outcomes (1)

• The percentage of microorganisms positive for cryptogenic organizing pneumonia detected by NGS

  The patients with cryptogenic organizing pneumonia will be detected through electronic bronchoscopy and lung puncture. The sample will be examinated through NGS.

  From 1 Dec 2019 to 1 Dec 2024

Interventions

Next-generation sequencing DIAGNOSTIC_TEST

The patient who may be diagnosed with cryptogenic organizing pneumonia will be detected through next-generation sequencing.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patients with cryptogenic organizing pneumonia

You may qualify if:

• The patient was older than 18 years old.
• The patient was organizing pneumonia (OP) through pathology.
• The patient was diagnosed as OP from clear cause through routine detection.
• Chest CT shows consolidation or ground glass

You may not qualify if:

• The patient has specific characteristics of connective tissue disease or autoimmune disease.
• The patient has a clear other cause of OP.
• The patient has severe systemic diseases of heart, brain, liver, kidney and so on, and cannot tolerate invasive examination
• The patient disapproves of invasive testing

Sponsors & Collaborators

• Shanghai Pulmonary Hospital, Shanghai, China: lead

Study Sites (2)

BAI Jiu-wu

Shanghai, Please Select, 200433, China

RECRUITING

Shanghai Pulmonary Hospital, Tongji University

Shanghai, Shanghai Municipality, 200000, China

RECRUITING

MeSH Terms

Conditions

Cryptogenic Organizing Pneumonia; Idiopathic Interstitial Pneumonias

Condition Hierarchy (Ancestors)

Organizing Pneumonia; Bronchiolitis Obliterans; Bronchiolitis; Bronchitis; Bronchial Diseases; Respiratory Tract Diseases; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Lung Diseases, Interstitial; Lung Diseases; Lung Diseases, Obstructive

Central Study Contacts

Jin-fu XU, M.D

CONTACT

8621-65115006; jfxucn@163.com

Jiu-wu BAI, M.D

CONTACT

8621-65115006; yv59@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of respiratory and Critical Care Medicine

Study Record Dates

• First Submitted: April 26, 2020
• First Posted: August 13, 2020
• Study Start: August 7, 2020
• Primary Completion: September 1, 2024
• Study Completion: December 1, 2024
• Last Updated: September 1, 2020

Record last verified: 2020-08

Locations

CN (2)