RAAS and Arterial Stiffness in SCI
Orthostatic Blood Pressure and Arterial Stiffness in Persons With SCI: The Effect of RAAS System
1 other identifier
observational
33
1 country
1
Brief Summary
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2018
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 30, 2018
CompletedFirst Submitted
Initial submission to the registry
August 10, 2020
CompletedFirst Posted
Study publicly available on registry
August 12, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2020
CompletedResults Posted
Study results publicly available
February 20, 2025
CompletedFebruary 20, 2025
February 1, 2025
2.4 years
August 10, 2020
June 26, 2023
February 18, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Pulse Wave Velocity (m/s)
Determine average pulse wave velocity among the three groups.
2 years
Secondary Outcomes (3)
Systolic Blood Pressure (mmHg)
2 years
Plasma Renin (pg/ml)
2 years
Norepinephrine (pg/ml)
2 years
Study Arms (3)
Cervical SCI
Ages between 21-70 years old Injured between C1-T1 Wheelchair dependent AIS classification of A, B or C Injury occurred more than 1 year ago
Thoracic SCI
Ages between 21-70 Injured between T6-T12 Wheelchair dependent AIS classification of A, B or C Injury occurred more than 1 year ago
Able-bodied Control
Ages between 21-70
Interventions
Eligibility Criteria
Outpatient individuals with SCI, flyers in town
You may qualify if:
- SCI participants:
- injured between C1-T1 and T6-T12
- wheelchair dependent
- AIS classification A, B or C
- Injured occurred more than 1 year ago
You may not qualify if:
- currently have an illness or infection
- current smoker of at least 1 year
- controlled or uncontrolled hypertension or diabetes mellitus
- Neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease)
- cardiovascular disease (coronary heart disease, congestive heart failure, peripheral artery disease)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- James J. Peters Veterans Affairs Medical Centerlead
- Kessler Foundationcollaborator
- Seton Hall Universitycollaborator
Study Sites (1)
James J Peters VAMC
The Bronx, New York, 10468, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Caitlyn Peters
- Organization
- James J Peters VA Medical Center
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- FED
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
August 10, 2020
First Posted
August 12, 2020
Study Start
June 30, 2018
Primary Completion
December 1, 2020
Study Completion
December 1, 2020
Last Updated
February 20, 2025
Results First Posted
February 20, 2025
Record last verified: 2025-02