Optic Nerve Sheath Diameter, Carotid Duplex and Transcranial Duplex as a Prognostic Factor

NCT04510363 | Recruiting

• 1 other identifier: 201911027RINC
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Optic nerve sheath diameter (ONSD) had been proved to be associated with increased intracranial pressure and can be used as one of the prognostic factors in cardiac arrest patients. It is simple, quick and can be measured repeatedly. Carotid duplex and transcranial duplex(TCD) provide rapid, noninvasive, real-time measures of cerebrovascular function. It can be used to assess the vascular territory by measuring blood flow, and to evaluate factors include brain perfusion, plaque morphology, and patency of intracranial collaterals. Hence, it could act as a crucial role in neuroprognosis in post-arrest patients. In this study, the investigator aimed to analyze the ONSD diameters, ONSD/external transverse diameter (ETD) ratio, carotid duplex and transcaranial duplex parameters in different stages of post-cardiac arrest care, demographic characteristics and resuscitation information with the neurological outcome of post-cardiac arrest patients. The ONSD diameter, and ONSD/ETD ratio were compared with age-, and sex-matched normal volunteers.

Conditions

Neurologic Dysfunction

Outcome Measures

Primary Outcomes (3)

• optic nerve sheath diameter (ONSD)

  ONSD measured by ultrasonography during the post-arrest care

  7 days

• carotid artery resistance

  carotid artery resistance measured by ultrasonography during the post-arrest care

  7 days

• middle cerebral artery resistance

  middle cerebral artery resistance measured by ultrasonography during the post-arrest care

  7 days

Study Arms (2)

cardiac arrest survivors

cardiac arrest survivors

age- and sex-matched controls

age- and sex-matched controls

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Non-traumatic cardiac arrest adult patients achieving return of spontaneous circulation after resuscitation

You may qualify if:

• Non-traumatic cardiac arrest adult patients achieving return of spontaneous circulation after resuscitation

You may not qualify if:

• traumatic cardiac arrests
• non-traumatic arrest patients without return of spontaneous circulation after resuscitation

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

MeSH Terms

Conditions

Neurologic Manifestations

Condition Hierarchy (Ancestors)

Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Wan-Ching Lien, PhD

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wan-Ching Lien, PhD

CONTACT

+886-223123456; wanchinglien@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 2, 2020
• First Posted: August 12, 2020
• Study Start: December 17, 2019
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: May 21, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)