Exercise Training to Atrial Fibrillation

NCT04508478 | Active Not Recruiting

• 1 other identifier: 202007030RINC
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

To test the impacts of different exercise training programs to the cardiopulmonary function, muscle metabolism, and body mass composition

Conditions

Atrial Fibrillation

Keywords

Atrial Fibrillation; weight training; aerobic training; cardio-pulmonary function

Outcome Measures

Primary Outcomes (3)

• AF burden

  AF burden on 14 day ECＧ

  5 months

• CPET/6 minute walking test

  CPET/6 minute walking test

  5 months

• DEXA/muscle MRI

  DEXA/muscle MRI

  5 months

Study Arms (3)

Aerobic training

EXPERIMENTAL

Behavioral: Aerobic training

Resistance training

ACTIVE COMPARATOR

Behavioral: Resistance training

Control

PLACEBO COMPARATOR

Behavioral: Control physical exercise

Interventions

Aerobic training BEHAVIORAL

Aerobic training

Aerobic training

Resistance training BEHAVIORAL

Resistance training

Resistance training

Control physical exercise BEHAVIORAL

Control physical exercise

Control

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Paroxysmal or persistent atrial fibrillation
• Daily activity below moderate intensity \< 300 minutes or high intensity \< 150 minutes per week.

You may not qualify if:

• Active infection.
• Implant cardiac pacemaker.
• Uncontrolled hypertension.
• Cardiopulmonary contraindication to exercise training, such as decompensated heart failure, acute pulmonary edema, unstable angina, uncontrolled arrhythmia causing hemodynamic compromise, symptomatic severe aortic stenosis, suspected dissecting aortic aneurysm, severe pulmonary hypertension, acute myocarditis, endocarditis or pericarditis, uncontrolled asthma and SpO2 \< 90% at rest on room air.
• Inability to follow verbal command or to walk on treadmill or use stationary bike.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Atrial Fibrillation

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Chih-Chieh Yu, MD.PhD

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 9, 2020
• First Posted: August 11, 2020
• Study Start: November 3, 2021
• Primary Completion: December 31, 2024
• Study Completion (Estimated): December 31, 2026
• Last Updated: August 19, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)