A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis
UPHOLD
Upadacitinib Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Moderate to Severe Rheumatoid Arthritis Patients in Real-World Practice (UPHOLD)
1 other identifier
observational
1,532
18 countries
258
Brief Summary
Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. This study will assess the treatment patterns, achievement of treatment targets and maintenance of response. Upadacitinib is a drug approved for the treatment of moderately to severely active rheumatoid arthritis. Adult participants with moderate to severe RA who have been prescribed upadacitinib by their physicians will be enrolled. Approximately, 1660 participants will be enrolled this study, worldwide. Participants will not receive Upadacitinib as part of this study, but will be followed for response to treatment for up to 24 months. There may be higher burden for participants in this trial compared to their standard of care. Participants will attend regular visits, every 3 months, during the course of the study at a hospital or clinic and will be asked to provide additional information by questionnaire at each visit.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2020
Typical duration for all trials
258 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 30, 2020
CompletedFirst Posted
Study publicly available on registry
August 4, 2020
CompletedStudy Start
First participant enrolled
October 16, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 15, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
May 15, 2024
CompletedApril 13, 2025
April 1, 2025
3.6 years
July 30, 2020
April 10, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Percentage of Participants Who Achieve Remission
Remission is defined as Disease Activity Score at 28 joints (DAS28) C-reactive Protein (CRP)\<2.6.
At Month 6
Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission
Remission is defined as DAS28-CRP\<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.
At Month 12
Secondary Outcomes (23)
Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission
At Month 24
Percentage of Participants Who Achieve Low Disease Activity (LDA) at 6 months that maintain LDA
Through Month 24
Percentage of Participants Who Achieve Remission at 3 Months and Maintain Remission
Through Month 24
Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission Grouped by Glucocorticoid Dose
At Month 12
Percentage of Participants Who Achieve LDA at 3 months that maintain LDA Grouped by Glucocorticoid Dose
Through Month 6
- +18 more secondary outcomes
Study Arms (1)
Participants receiving Upadacitinib
Participants receiving Upadacitinib for moderate to severe rheumatoid arthritis (RA).
Eligibility Criteria
Adults receiving Upadacitinib according to the product prescribing information, for moderate to severe active Rheumatoid Arthritis (RA).
You may qualify if:
- Confirmed diagnosis of moderate to severe active Rheumatoid Arthritis (RA).
- Physician decision on patient treatment with upadacitinib must have been reached prior to and independently of recruitment in the study.
- Upadacitinib prescribed in accordance to the applicable approved label and local regulatory and reimbursement policies.
- French Participants Only: Taking oral glucocorticoids ≥5 mg/day of prednisone or equivalent for at least 3 months prior to study start.
You may not qualify if:
- \- Prior treatment with Upadacitinib.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AbbVielead
Study Sites (263)
Hospital Italiano La Plata /ID# 222190
La Plata, Buenos Aires, 1902, Argentina
CER Instituto Medico /ID# 222193
Quilmes, Buenos Aires, 1878, Argentina
Organizacion Medica de Investigacion (OMI) /ID# 222187
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1015, Argentina
CIER Centro de Investigaciones en Enfermedades Reumaticas /ID# 231769
Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1055, Argentina
Instituto CAICI S.R.L /ID# 222191
Rosario, Santa Fe Province, 2000, Argentina
CIMER Centro Integral de Medicina Respiratoria /ID# 222188
San Miguel de Tucumán, Tucumán Province, 4000, Argentina
DOM Centro de Reumatologia /ID# 222194
Buenos Aires, 1111, Argentina
Instituto Medico Strusberg /ID# 222189
Córdoba, 5000, Argentina
Instituto de Cardiologia /ID# 226634
Santiago del Estero, 4200, Argentina
Genesis Research Services /ID# 224060
Broadmeadow, New South Wales, 2292, Australia
BJC Health /ID# 223884
Paramatta, New South Wales, 2150, Australia
Private Practice - Scott Walter Graf /ID# 223958
Adelaide, South Australia, 5000, Australia
Emeritus Research /ID# 223883
Camberwell, Victoria, 3124, Australia
Joint West Rheumatology /ID# 223886
Murdoch, Western Australia, 6150, Australia
Klinikum Klagenfurt am Wörthersee /ID# 239628
Klagenfurt, Carinthia, 9020, Austria
Ordination Dr. Leeb /ID# 224293
Hollabrunn, Lower Austria, 2020, Austria
Dr. Georg Kurtz /ID# 225477
Gleisdorf, Styria, 8200, Austria
Dr. Maya Thun /ID# 224299
Vienna, Vienna, 1010, Austria
Ordination Doz. Grisar /ID# 224298
Vienna, Vienna, 1090, Austria
Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 227853
Vienna, Vienna, 1100, Austria
CHU Saint Pierre /ID# 223041
Brussels, Brussels Capital, 1000, Belgium
Rhumaconsult SPRL /ID# 221825
Charleroi, Hainaut, 6000, Belgium
Reuma Instituut Hasselt /ID# 221822
Hasselt, Limburg, 3500, Belgium
Duplicate_CHU UCL Namur - site Godinne /ID# 222797
Godinne, Namur, 5530, Belgium
Algemeen Stedelijk Ziekenhuis /ID# 224121
Aalst, Oost-Vlaanderen, 9300, Belgium
Private practice Sint-Niklaas /ID# 224123
Sint-Niklaas, Oost-Vlaanderen, 9100, Belgium
Onze Lieve Vrouw Hospital /ID# 223042
Aalst, 9300, Belgium
AZ Sint-Jan Brugge /ID# 223713
Bruges, 8000, Belgium
AZ Sint Lucas /ID# 223093
Bruges, 8310, Belgium
Reumacentrum /ID# 222799
Genk, 3600, Belgium
ReumaClinic /ID# 221353
Genk, 3600, Belgium
Maertens, Gistel, BE /ID# 221823
Gistel, 8470, Belgium
CHU de Liege /ID# 222201
Liège, 4000, Belgium
AZ Alma Campus Sijsele /ID# 222214
Sijsele, 8340, Belgium
Centre Hospitalier de Laon /ID# 224857
Laon, Aisne, 02001, France
Polyclinique saint Odilon /ID# 225576
Moulins, Allier, 03000, France
CH Cannes - les Broussailles /ID# 226160
Cannes, Alpes-Maritimes, 06414, France
CHU Strasbourg - Hopital de Hautepierre /ID# 222450
Strasbourg, Bas-Rhin, 67200, France
Hopital Saint Joseph /ID# 227221
Marseille, Bouches-du-Rhone, 13008, France
cabinet liberal- Dr CORNILLE /ID# 227869
Caen, Calvados, 14000, France
Centre Hospitalier d'Angouleme /ID# 226064
Angoulême, Charente, 16959, France
CHU Dijon /ID# 223799
Dijon, Cote-d Or, 21000, France
CH Georges Renon /ID# 225197
Niort, Deux-Sevres, 79028, France
CHU de Besancon - Jean Minjoz /ID# 222463
Besançon, Doubs, 25030, France
Cabinet de rhumatologie /ID# 227740
Mennecy, Essonne, 91540, France
Cabinet Rhumatologie St Michel Sur Orge /ID# 225176
Saint-Michel-sur-Orge, Essonne, 91240, France
Hopital de la Cavale Blanche /ID# 222462
Brest, Finistere, 29200, France
CH des Pays de Morlaix /ID# 223795
Morlaix, Finistere, 29600, France
CHU Limoges - Dupuytren 1 /ID# 222457
Limoges, Franche-Comte, 87042, France
CHU Bordeaux - Hopital Pellegrin /ID# 224837
Bordeaux, Gironde, 33076, France
CHU Toulouse - Hopital Purpan /ID# 223150
Toulouse, Haute-Garonne, 31059, France
CH Bigorre - Site de la Gespe /ID# 225141
Tarbes, Hautes-Pyrenees, 65013, France
CH Roubaix - Hopital Victor Provo /ID# 225032
Roubaix, Hauts-de-France, 59100, France
Clinique Beau Soleil /ID# 224238
Montpellier, Herault, 34070, France
CHU Montpellier - Hopital Saint Eloi /ID# 222452
Montpellier, Herault, 34295, France
CHU Montpellier - Hopital Saint Eloi /ID# 223394
Montpellier, Herault, 34295, France
CHU Grenoble - Hopital Michallon /ID# 223211
La Tronche, Isere, 38700, France
Cabinet médical /ID# 225000
Les Abrets En Dauphine, Isere, 38490, France
Cabinet médical /ID# 225321
Reims, Marne, 51100, France
Cabinet de Rhumatologie Poincare /ID# 224755
Thionville, Moselle, 57100, France
Cabinet liberal - Compiegne - Dr Banse /ID# 227099
Compiègne, Oise, 60200, France
Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 222986
Paris, Paris, 75679, France
CHU de Nantes, Hotel Dieu -HME /ID# 225787
Nantes, Pays de la Loire Region, 44000, France
CH Roanne /ID# 224729
Roanne, Pays de la Loire Region, 42300, France
CHU Nice -Hopital Pasteur /ID# 222460
Nice, Provence-Alpes-Côte d'Azur Region, 06002, France
Infirmerie Protestante /ID# 222438
Caluire-et-Cuire, Rhone, 69300, France
HCL - Hopital Lyon Sud /ID# 222447
Pierre-Bénite, Rhone, 69495, France
Cabinet medical /ID# 225366
Aix-les-Bains, Savoie, 73100, France
CHU Amiens-Picardie Site Sud /ID# 222444
Amiens, Somme, 80054, France
Cabinet libéral du Dr PAUPIERE /ID# 238723
Péronne, Somme, 80200, France
Cabinet medical /ID# 224850
Albi, Tarn, 81000, France
CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 229086
La Roche-sur-Yon, Vendee, 85000, France
CH du Pays d'AIX /ID# 229561
Aix-en-Provence, 13616, France
Cabinet Novel d'Annecy /ID# 232310
Annecy, 74000, France
Centre Hospitalier d'Arras /ID# 223172
Arras, 62022, France
Centre Hospitalier de Boulogne Sur Mer /ID# 222991
Boulogne-sur-Mer, 62200, France
Centre Hospitalier Jean Rougie /ID# 224242
Cahors, 46005, France
CHRU Tours - Hopital Trousseau /ID# 222445
Chambray-lès-Tours, 37170, France
Centre Hospitalier de CHOLET /ID# 222455
Cholet, 49300, France
Hia Percy /Id# 225642
Clamart, 92190, France
CHU Clermont Ferrand - Hopital Gabriel Montpied /ID# 223801
Clermont-Ferrand, 63000, France
C. H. Sud Francilien /ID# 222446
Corbeil-Essonnes, 91106, France
Cabinet medical /ID# 225142
Haguenau, 67500, France
CH La Rochelle - Hopital Saint Louis /ID# 224240
La Rochelle, 17019, France
CH Emile Roux Le Puy en Velay /ID# 223688
Le Puy-en-Velay, 43000, France
CHU Lille - Hôpital Roger Salengro /ID# 223170
Lille, 59037, France
Clinique de la Sauvegarde /ID# 223424
Lyon, 69009, France
CH Princesse Grace /ID# 222451
Monaco, 98000, France
Ch Montauban /Id# 231854
Montauban, 82000, France
ELSAN - Clinique du Pont de Chaume /ID# 224898
Montauban, 82000, France
Ch Mulhouse /Id# 223442
Mulhouse, 68100, France
Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 223591
Orléans, 45067, France
AP-HP - Hopital Saint-Antoine /ID# 222441
Paris, 75012, France
Hopital Pitie Salpetriere /ID# 222443
Paris, 75013, France
Cabinet medical /ID# 224855
Paris, 75014, France
Centre de Soins Osteoarticulaires Ambulatoires /ID# 224737
Paris, 75015, France
AP-HP - Hopital Bichat - Claude-Bernard /ID# 222449
Paris, 75018, France
GH Diaconesses Croix Saint-Simon /ID# 229126
Paris, 75020, France
CHU de Rennes - Hospital Sud /ID# 222458
Rennes, 35203, France
Clinique Saint-Hilaire /ID# 223833
Rouen, 76000, France
Hôpital Charles-Nicolle /ID# 223589
Rouen, 76000, France
Hôpital d'instruction des armées Bégin /ID# 222440
Saint-Mandé, 94163, France
CH Saint Nazaire /ID# 225750
Saint-Nazaire, 44600, France
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 222456
Saint-Priest-en-Jarez, 42270, France
Cabinet rhumatologie Dr NECTOUX /ID# 225828
Sainte-Maxime, 83120, France
Groupe Médical Spécialisé - Le Premium /ID# 223719
Strasbourg, 67000, France
Hopital Avicenne - APHP /ID# 224248
Bobigny, Île-de-France Region, 93000, France
Praxis Dr. Haas /ID# 225187
Tübingen, Baden-Wurttemberg, 72072, Germany
Rheumatologische-Immunologische Praxis Templin /ID# 226924
Templin, Brandenburg, 17268, Germany
ACURA Rheumazentrum Baden-Bade /ID# 225225
Baden-Baden, 76530, Germany
Rheumapraxis Prof Dr Karin Manger /ID# 224086
Bamberg, 96047, Germany
Praxis fuer Rheumatologie und Innere Medizin /ID# 225222
Berlin, 12163, Germany
Eisterhues, Braunschweig, DE /ID# 225186
Braunschweig, 38100, Germany
Rheumatologie in Veedel /ID# 224999
Cologne, 50825, Germany
Dres. Karger/Baerlecken /ID# 224809
Cologne, 50996, Germany
Praxis Dilltal /ID# 226925
Ehringshausen, 35630, Germany
MVZ Ambulantes Rheumazentrum Erfurt /ID# 224812
Erfurt, 99096, Germany
Helios Fachklinik Vogelsang-Gommern /ID# 222949
Gommern, 39245, Germany
Asklepios MVZ Nord SH GmbH /ID# 225048
Hamburg, 20097, Germany
Heilig, Heidelberg, DE /ID# 225223
Heidelberg, 69120, Germany
Praxis internistische Rheumatologie /ID# 239226
Leipzig, 04129, Germany
Dres. Teipel/Toussaint/Saech /ID# 226923
Leverkusen, 51373, Germany
Aurich & Sieburg, Magdeburg /ID# 230701
Magdeburg, 39104, Germany
Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 223866
Pfarrkirchen, 84347, Germany
MVZ für Rheumatologie Dr. M. Welcker /ID# 226926
Planegg, 82152, Germany
Krankenhaus der Barmherzigen Brüder Trier /ID# 226927
Trier, 54292, Germany
Olympion General Clinic /ID# 224130
Pátrai, Achaia, 25443, Greece
251 Airforce General Hospital /ID# 225065
Athens, Attica, 11525, Greece
General Hospital of Athens Gennimatas /ID# 225064
Athens, Attica, 11527, Greece
General Hospital of Athens Ippokratio /ID# 224164
Athens, Attica, 11527, Greece
University General Hospital Attikon /ID# 224136
Athens, Attica, 12462, Greece
General Hospital Asklepieio Voulas /ID# 224131
Athens, Attica, 16673, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 224133
Heraklion, Crete, 71500, Greece
University General Hospital of Alexandroupolis /ID# 224880
Alexandroupoli, Evros, 68100, Greece
Naval Hospital of Athens /ID# 224135
Athens, 11521, Greece
General Hospital of Patras Agios Andreas /ID# 224132
Pátrai, 26335, Greece
Bioclinic Thessaloniki /ID# 224879
Thessaloniki, 54622, Greece
General Hospital of Thessaloniki Hippokrateio /ID# 229965
Thessaloniki, 54642, Greece
Euromedica General Clinic /ID# 224134
Thessaloniki, 54645, Greece
St James Hospital /ID# 224201
Dublin, Dublin, D08 NHY1, Ireland
Hermitage Medical Clinic /ID# 239556
Dublin, Dublin, D20 W722, Ireland
St Vincent's University Hospital /ID# 224200
Elm Park, Dublin, D04 T6F4, Ireland
Tallaght University Hospital /ID# 231260
Tallaght, Dublin, D24 NR0A, Ireland
Meir Medical Center /ID# 222116
Kfar Saba, Central District, 4428164, Israel
HaEmek Medical Center /ID# 222138
Afula, H_efa, 1834111, Israel
Hillel Yaffe Medical Center /ID# 222170
Hadera, H_efa, 38100, Israel
Rambam Health Care Campus /ID# 222118
Haifa, H_efa, 3109601, Israel
The Lady Davis Carmel Medical Center /ID# 223851
Haifa, H_efa, 34362, Israel
Galilee Medical Center /ID# 222113
Nahariya, Northern District, 2210001, Israel
The Chaim Sheba Medical Center /ID# 222034
Ramat Gan, Tel Aviv, 5265601, Israel
Tel Aviv Sourasky Medical Center /ID# 222117
Tel Aviv, Tel Aviv, 6423906, Israel
Rabin Medical Center /ID# 222694
Haifa, 4941492, Israel
Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 229440
Torette, Ancona, 60020, Italy
Azienda Ospedaliero Universitaria di Ferrara - Ospedale Sant'Anna /ID# 228788
Cona, Ferrara, 44124, Italy
ASL 3 Genovese - Ospedale la Colletta /ID# 228892
Arenzano, Genova, 16011, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 229061
Rome, Lazio, 00168, Italy
Ospedale San Raffaele IRCCS /ID# 229059
Milan, Milano, 20132, Italy
ASST Grande Ospedale Metropolitano Niguarda /ID# 228807
Milan, Milano, 20162, Italy
Istituto Clinico Humanitas /ID# 227943
Rozzano, Milano, 20089, Italy
Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 229063
Rome, Roma, 00128, Italy
Sapienza University /ID# 228014
Rome, Roma, 00161, Italy
Ospedale Mauriziano di Torino /ID# 228888
Turin, Torino, 10128, Italy
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 228889
Alessandria, 15100, Italy
Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 228580
Bari, 70124, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 228967
Bergamo, 24127, Italy
ASST Spedali civili di Brescia /ID# 228970
Brescia, 25123, Italy
Ospedale Ss. Annunziata /ID# 228809
Chieti, 66100, Italy
ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 228556
Milan, 20122, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 228554
Modena, 41124, Italy
AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 229057
Napoli, 80138, Italy
Ospedale San Giovanni Bosco /ID# 228552
Napoli, 80144, Italy
Azienda Ospedaliera Civico Di Cristina Benfratelli- P.O. Civico /ID# 228912
Palermo, 90127, Italy
Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228160
Palermo, 90127, Italy
Fondazione IRCCS Policlinico /ID# 227937
Pavia, 27100, Italy
Azienda Ospedaliero Universitaria Pisana /ID# 228550
Pisa, 56126, Italy
Azienda Ospedaliera Regionale San Carlo /ID# 228648
Potenza, 85100, Italy
Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 227942
Rome, 00189, Italy
Azienda Ospedaliera Universitaria "San Giovanni di Dio e Ruggi d'Aragona /ID# 229065
Salerno, 84131, Italy
Azienda Ospedaliero-Universitaria Senese-Ospedale Santa Maria delle Scotte /ID# 227938
Siena, 53100, Italy
Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 228551
Udine, 33100, Italy
Azienda Ospedaliera Universitaria di Verona/Ospedale Borgo Trento /ID# 228553
Verona, 37126, Italy
Mubarak Hospital /ID# 224139
Hawalli, 46300, Kuwait
Ameeri Hospital /ID# 224140
Kuwait City, 35002, Kuwait
KOC Hospital /ID# 224138
Kuwait City, 60000, Kuwait
Centro Integral en Reumatologia S.A de C.V /ID# 224363
Guadalajara, Jalisco, 44160, Mexico
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 224361
Guadalajara, Jalisco, 44650, Mexico
Private Office Dr. Orozco /ID# 243257
Guadalajara, Jalisco, 44650, Mexico
Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 224364
Guadalajara, Jalisco, 44690, Mexico
RM Pharma Specialists S.A de C.V. /ID# 224359
Mexico City, Mexico City, 03100, Mexico
CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 240836
Mexico City, Mexico City, 11850, Mexico
Consultorio Medico Privado - Miryam Eguia Bernal /Id# 243255
Monterrey, Nuevo León, 64000, Mexico
Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 224360
Mexico City, 11650, Mexico
Consultorio Privado Jorge Rojas Serrano /Id# 243258
Puebla City, 72550, Mexico
LLC MC RevmaMed /ID# 239162
Syktyvkar, Komi, 167031, Russia
Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 224852
Moscow, Moscow Oblast, 129110, Russia
Samara Regional Clinical Hospital n.a. V. D. Seredavin /ID# 227852
Samara, Samara Oblast, 443095, Russia
Nort-Western State Medical University n.a. Mechnikov /ID# 223419
Saint Petersburg, Sankt-Peterburg, 193015, Russia
GBUZ TO Regional Clinical Hospital No. 1 /ID# 241113
Tyumen, Tyumen Oblast, 625032, Russia
District clinical hospital /ID# 227662
Khanty-Mansyisk, 628011, Russia
City Clinical Hospital #52 /ID# 242947
Moscow, 123182, Russia
Omsk Regional Clinic Hospital /ID# 232029
Omsk, 644111, Russia
Orenburg State Medical University /ID# 243615
Orenburg, 460000, Russia
Republican hospital named after V.A. Baranov /ID# 227661
Petrozavodsk, 185019, Russia
Clinical Rheumatologic Hospital No 25 /ID# 242475
Saint Petersburg, 190068, Russia
Military Medical Academy n.a. Kirov /ID# 242351
Saint Petersburg, 194044, Russia
Clinic of Samara State Medical University /ID# 241168
Samara, 443079, Russia
Budgetary Institution of the Khanty-Mansiysk Autonomous Okrug-Yugra Surgut Dist /ID# 243313
Surgut, 628400, Russia
Nebbiolo Clinical Research Center /ID# 224900
Tomsk, 634009, Russia
Ulyanovsk Regional Clinical Hospital /ID# 239164
Ulyanovsk, 432017, Russia
Voronezh State Medical Univers /ID# 224854
Voronezh, 394036, Russia
Yaroslavl State Medicat University /ID# 224851
Yaroslavl, 150000, Russia
Saudi German Hospital Jeddah /ID# 243234
Jeddah, 22236, Saudi Arabia
King Abdulaziz University Hospital /ID# 222724
Jeddah, 22252, Saudi Arabia
International Medical Center /ID# 243235
Jeddah, 22382, Saudi Arabia
Saudi German Hospital /ID# 224137
Mushait, 61961, Saudi Arabia
King Fahad Medical City /ID# 222917
Riyadh, 11525, Saudi Arabia
Complejo Hospitalario Universitario A Coruña /ID# 231818
A Coruña, A Coruna, 15006, Spain
Hospital de Mérida /ID# 231826
Mérida, Badajoz, 06800, Spain
Hospital Universitari Mútua Terrassa /ID# 231822
Terrassa, Barcelona, 08221, Spain
Hospital de Viladecans /ID# 231823
Viladecans, Barcelona, 08840, Spain
Hospital Virgen del Puerto /ID# 240149
Plasencia, Caceres, 10600, Spain
Hospital Universitario de Jerez de la Frontera /ID# 231844
Jerez de la Frontera, Cadiz, 11407, Spain
Hospital Universitario Reina Sofia /ID# 231843
Córdoba, Cordoba, 14004, Spain
Hospital Universitario de Getafe /ID# 231825
Getafe, Madrid, 28905, Spain
Hospital General Universitario Santa Lucia /ID# 238780
Cartagena, Murcia, 30202, Spain
Hospital Clinico Universitario Virgen de la Arrixaca /ID# 231847
El Palmar, Murcia, 30120, Spain
Hospital Rafael Mendez /ID# 231846
Lorca, Murcia, 30817, Spain
Hospital Xeral Cies (CHUVI) /ID# 231819
Vigo, Pontevedra, 36204, Spain
Hospital Universitario Canarias /ID# 231848
San Cristóbal de La Laguna, Santa Cruz De Tenerife, 38320, Spain
Hospital Ernest Lluch Martin /ID# 238779
Calatayud, Zaragoza, 50299, Spain
Hospital Universitario Torrecardenas /ID# 241931
Almería, 04009, Spain
Hospital Perpetuo Socorro /ID# 231827
Badajoz, 06010, Spain
Hospital Parc de Salut del Mar /ID# 240000
Barcelona, 08003, Spain
Hospital Santa Creu i Sant Pau /ID# 231821
Barcelona, 08041, Spain
Hospital General de Granollers /ID# 238778
Barcelona, 08042, Spain
Hospital Universitario Virgen de las Nieves /ID# 231841
Granada, 18014, Spain
Hospital Juan Ramon Jimenez /ID# 231840
Huelva, 21005, Spain
Hospital Universitario de Jaen /ID# 231842
Jaén, 23007, Spain
Hospital Universitario Ramon y Cajal /ID# 241901
Madrid, 28034, Spain
Hospital Universitario Virgen de la Victoria /ID# 240150
Málaga, 29010, Spain
Hospital Universitario Virgen Macarena /ID# 231837
Seville, 41009, Spain
Hospital Universitario Virgen del Rocio /ID# 231836
Seville, 41013, Spain
Hospital Universitario Virgen de Valme /ID# 231838
Seville, 41014, Spain
Hospital Royo Villanova /ID# 231824
Zaragoza, 50015, Spain
Kantonsspital Aarau AG /ID# 222354
Aarau, Canton of Aargau, 5001, Switzerland
Universitätsspital Basel /ID# 224160
Basel Town, Canton of Basel-City, 4031, Switzerland
Kantonsspital St. Gallen /ID# 224158
Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
CHUV, Centre hospitalier universitaire vaudois /ID# 224161
Lausanne, Canton of Vaud, 1011, Switzerland
Rheumatologisches Versorgungszentrum Weinfelden /ID# 222346
Weinfelden, Thurgau, 8570, Switzerland
Inselspital, Universitaetsspital Bern /ID# 224951
Bern, 3010, Switzerland
HFR Fribourg - Hôpital cantonal /ID# 224163
Fribourg, 1708, Switzerland
National Taiwan University Hospital /ID# 241050
Taipei City, Taipei, 100, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 241052
Kaohsiung City, 807, Taiwan
China Medical University Hospital /ID# 241051
Taichung, 40447, Taiwan
Chi-Mei Medical Center /ID# 241745
Tainan, 71004, Taiwan
Tri-Service General Hospital /ID# 241746
Taipei, 11490, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 241053
Taoyuan, 333, Taiwan
Cleveland Clinic Abu Dhabi /ID# 223176
Abu Dhabi, United Arab Emirates
Integrated Rheumatology and Arthritis Center /ID# 223177
Dubai, 334224, United Arab Emirates
Departnent of Medicine-Rheumatology Al Baraha Hospital and Al Qasmi Hospital Min /ID# 223178
Dubai, United Arab Emirates
Drt Sulaiman Al Habib Hospital /ID# 226575
Dubai, United Arab Emirates
Asociacion Española /ID# 222009
Montevideo, 11200, Uruguay
Medica Uruguaya /ID# 222008
Montevideo, 11600, Uruguay
Related Publications (1)
Ostor A, Feist E, Sidiropoulos P, Avouac J, Rebella M, Namas R, McDearmon-Blondell E, Gao T, Lagunes-Galindo I, Strengholt S, Zisman D, Attar S. Achievement of treatment targets and maintenance of response with upadacitinib in patients with moderate-to-severe rheumatoid arthritis in real-world practice: 1-year outcomes from the UPHOLD observational study. Arthritis Res Ther. 2025 Apr 10;27(1):84. doi: 10.1186/s13075-025-03528-5.
PMID: 40211417DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
ABBVIE INC.
AbbVie
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 30, 2020
First Posted
August 4, 2020
Study Start
October 16, 2020
Primary Completion
May 15, 2024
Study Completion
May 15, 2024
Last Updated
April 13, 2025
Record last verified: 2025-04