NCT04487197

Brief Summary

Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
282

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2020

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 15, 2020

Completed
9 days until next milestone

First Submitted

Initial submission to the registry

July 24, 2020

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 27, 2020

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 15, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 15, 2021

Completed
Last Updated

February 10, 2021

Status Verified

February 1, 2021

Enrollment Period

6 months

First QC Date

July 24, 2020

Last Update Submit

February 9, 2021

Conditions

Keywords

COVID-19 infectionTransplanted patientskidney transplantspancreas transplantspancreatic islet transplantation

Outcome Measures

Primary Outcomes (2)

  • Serum-prevalence of COVID-19 TX

    Evaluation of serum-prevalence data transplanted patients (symptomatic vs asymptomatic patients)

    From 15 July 2020 to 15 January 2021

  • Serum-prevalence of COVID-19 / Age, Gender, Type of transplantation, comorbities, Italian regions-proviences transplanted patients

    Correlation serum-prevalence of COVID-19 / Age, Gender, Type of transplantation, comorbities, Italian regions-proviences transplanted patients

    From 15 July 2020 to 15 January 2021

Secondary Outcomes (4)

  • Asymptomatic or subclinical infections in transplanted patients

    From 15 July 2020 to 15 January 2021

  • Risk factors for infection COVID-19 transplanted patients

    From 15 July 2020 to 15 January 2021

  • Hospitalization rate COVID-19 transplanted patients

    From 15 July 2020 to 15 January 2021

  • Mortality rate COVID-19 transplanted patients

    From 15 July 2020 to 15 January 2021

Study Arms (2)

Cohort 1

* Adult patients (age ≥ 18 years), * kidney or pancreas or pancreatic islets transplantation * transplanted patients (period: 01.01.2020 to 30.06.2020)

Procedure: blood sample for seroepidemiological investigation

Cohort 2

* Adult patients (age ≥ 18 years), * kidney or pancreas or pancreatic islets transplantation * Transplanted patients in follow-up since 01.01.2020 or trasplanted patients after 30.06.2020.

Procedure: blood sample for seroepidemiological investigation

Interventions

blood sample for seroepidemiological investigation

Cohort 1Cohort 2

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Transplanted Kidney, Pancreas or Pancreatic Islet patients

You may qualify if:

  • Adult patients (age ≥ 18 years),
  • Kidney or pancreas or pancreatic islets transplantation
  • Transplanted patients (period: 01.01.2020 to 30.06.2020)
  • Informed Consent signed
  • Adult patients (age ≥ 18 years),
  • Kidney or pancreas or pancreatic islets transplantation
  • transplanted patients in follow-up since 01.01.2020 or trasplanted patients after 30.06.2020.
  • Informed Consent signed

You may not qualify if:

  • Symptomatology such as fever\> 37.5, and / or cough and / or respiratory distress and / or diarrhea / vomiting in 14 days prior to collection of blood sample

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

IRCCS San Raffaele

Milan, 20132, Italy

Location

MeSH Terms

Conditions

COVID-19

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Specimen HandlingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisPuncturesSurgical Procedures, OperativeInvestigative Techniques

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

July 24, 2020

First Posted

July 27, 2020

Study Start

July 15, 2020

Primary Completion

January 15, 2021

Study Completion

January 15, 2021

Last Updated

February 10, 2021

Record last verified: 2021-02

Locations