NCT04486248

Brief Summary

In this project, we aim at implementing a te-ASL sequence and to compare it to two reference ASL sequences with a fixed PLD on healthy individuals. On the one hand, the te-ASL sequence will be compared against a 3D pCASL with a PLD of 1800 ms, as the current reference according the Consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. On the other, as the implemented te-ASL sequence will have a 2D readout, it will also be compared to a 2D pCASL ASL sequence with the same PLD, in order to be able to disentangle differences due to the dynamic PLD scheme from those arising from the different read-out schemes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Oct 2019

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 9, 2019

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 24, 2020

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

July 20, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 24, 2020

Completed
2.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2022

Completed
Last Updated

March 31, 2023

Status Verified

September 1, 2021

Enrollment Period

5 months

First QC Date

July 20, 2020

Last Update Submit

March 30, 2023

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

  • ASL perfusion MRI data

    Quantification of cerebral blood flow

    Through study completion, an average of 1 year

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Thirty (N=30) healthy individuals older than 18 years old

You may qualify if:

  • To sign the study informed consent form approved by the corresponding authorities.
  • Healthy men and women (older than 18 years old).

You may not qualify if:

  • Inability or unwillingness to give written informed consent or communicate with the study staff or illiteracy.
  • Any contraindication to perform brain MRI procedure (e.g. pacemaker, MRI-incompatible aneurysm clips).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

BarcelonaBeta Brain Research Center

Barcelona, 08005, Spain

Location

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 20, 2020

First Posted

July 24, 2020

Study Start

October 9, 2019

Primary Completion

February 24, 2020

Study Completion

December 31, 2022

Last Updated

March 31, 2023

Record last verified: 2021-09

Locations

ES(1)