Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans

NCT04485520 | Completed

• 1 other identifier: 00140
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Papaya has effects on oral pathogenic microorganisms, it also has anticoagulant quality, amebicidal action, antimicrobial, bacteriostatic and antifungal activity on different bacteria, especially on Streptococcus mutans, this can be exploited in the dental area. The objective of the study was to determine the efficacy of Carica Papaya peel extract (suckling) as an inhibitor of Streptococcus Mutans in students of the dental faculty of the National University of Caaguazú in 2018.

Conditions

Streptococcus, Other Specified Group; Dental Plaque

Keywords

Saliva; dental plaque; streptococcus mutans

Outcome Measures

Primary Outcomes (3)

• Number of Colony Forming units (Stage 1)

  Before Intervention

  thorough study completion, an average of 24 hours

• Number of Colony Forming units (Stage 2)

  After Intervention

  10 minutes after mouthwash use

• Number of Colony Forming units (Stage 3)

  After Intervention

  8 days after mouthwash use

Study Arms (2)

Carica Papaya extract

EXPERIMENTAL

Carica Papaya at 3%

Other: CARICA PAPAYA MOUTHWASH

Chlorhexidine

ACTIVE COMPARATOR

0.12% chlorhexidine mouthwash formulation (commercially available)

Other: CHLORHEXIDINE MOUTHWASH

Interventions

CARICA PAPAYA MOUTHWASH OTHER

Each application was 10 ml. applied for 1 minute, once a day for 8 days

Carica Papaya extract

CHLORHEXIDINE MOUTHWASH OTHER

Each application was 10 ml. applied for 1 minute, once a day for 8 days

Chlorhexidine

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants that signed the informed consent

You may not qualify if:

• allergic to carica papaya
• ongoing medical or dental treatment that could interfere with the results.

Sponsors & Collaborators

• Julieta María Méndez Romero: lead

Study Sites (1)

Facultad de Odontología Universidad Nacional de Caaguazú

Coronel Oviedo, International, 595, Paraguay

Location

Related Publications (1)

• Saliasi I, Llodra JC, Bravo M, Tramini P, Dussart C, Viennot S, Carrouel F. Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial. Int J Environ Res Public Health. 2018 Nov 27;15(12):2660. doi: 10.3390/ijerph15122660.

  PMID: 30486374 BACKGROUND

MeSH Terms

Conditions

Dental Plaque

Condition Hierarchy (Ancestors)

Dental Deposits; Tooth Diseases; Stomatognathic Diseases

Study Officials

• Diego Céspedes

  Facultad de Odontología, Universidad Nacional de Caaguazu

  PRINCIPAL INVESTIGATOR

• Ulises A Villasanti Torales

  Facultad de Odontologia, Universidad Nacional de Caaguazu

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head of Writting and Publication Department, Regional Health Research Institute

Study Record Dates

• First Submitted: July 21, 2020
• First Posted: July 24, 2020
• Study Start: September 21, 2017
• Primary Completion: October 21, 2017
• Study Completion: October 21, 2017
• Last Updated: August 18, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: From the time the protocol is available in clinical trials.gov and with no limit of time
• Access Criteria: Researchers that want to know about the study and use the protocol

Locations

PA (1)