Seroprevalence of Coronavirus Disease 2019 (COVID-19) Antibodies in a Vulnerable Neighbourhood, Buenos Aries Argentina

NCT04472078 | Completed

• 1 other identifier: 1831
• Study Type: observational
• Target: 873
• Locations: 1 country
• Sites: 1

Brief Summary

Background The study aimed to establish the seroprevalence of SARS-COV-2 in an Argentinian slum three months after the first case was reported. Methods Between June 10th and July 1st, a cross-sectional design was carried out on people over 14 years old, selected from a probabilistic sample of households. Finger prick puncture ELISA test

Conditions

SARS-CoV-2

Keywords

Slums; Seroprevalence study; Participatory Research; Coronavirus; Community health; Clustering

Outcome Measures

Primary Outcomes (1)

• to establish the seroprevalence of SARS-CoV-2

  Prevalence of positive IgG for SARS-CoV-2

  up to 20 weeks

Interventions

Serological Assay or IgG for SARS-CoV-2 DIAGNOSTIC_TEST

Serological Assay for detection of IgG for SARS-CoV-2

Eligibility Criteria

• Age: 14 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Barrio Mugica, Buenos Aires city, Argentina, This Barrio isone of the most overcrowded slums with more than 50.000 inhabitants, and almost 1500 people experiencing homelessness

You may qualify if:

• All subjects of 14 years or more who accept to be test

You may not qualify if:

• none

Sponsors & Collaborators

• Hospital Italiano de Buenos Aires: lead
• Hospital de Niños R. Gutierrez de Buenos Aires: collaborator
• Salud Comunitaria Ministerio de Salud GCBA: collaborator

Study Sites (1)

Hospital de Niños Ricardo Gutierrez

Buenos Aires, Buenos Aires F.D., 1425, Argentina

Location

Related Publications (9)

• Sood N, Simon P, Ebner P, Eichner D, Reynolds J, Bendavid E, Bhattacharya J. Seroprevalence of SARS-CoV-2-Specific Antibodies Among Adults in Los Angeles County, California, on April 10-11, 2020. JAMA. 2020 Jun 16;323(23):2425-2427. doi: 10.1001/jama.2020.8279.

  PMID: 32421144 BACKGROUND

• Pereira RJ, Nascimento GNLD, Gratao LHA, Pimenta RS. The risk of COVID-19 transmission in favelas and slums in Brazil. Public Health. 2020 Jun;183:42-43. doi: 10.1016/j.puhe.2020.04.042. Epub 2020 May 8. No abstract available.

  PMID: 32422438 BACKGROUND

• Corburn J, Vlahov D, Mberu B, Riley L, Caiaffa WT, Rashid SF, Ko A, Patel S, Jukur S, Martinez-Herrera E, Jayasinghe S, Agarwal S, Nguendo-Yongsi B, Weru J, Ouma S, Edmundo K, Oni T, Ayad H. Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements. J Urban Health. 2020 Jun;97(3):348-357. doi: 10.1007/s11524-020-00438-6.

  PMID: 32333243 BACKGROUND

• Moen EL, Fricano-Kugler CJ, Luikart BW, O'Malley AJ. Analyzing Clustered Data: Why and How to Account for Multiple Observations Nested within a Study Participant? PLoS One. 2016 Jan 14;11(1):e0146721. doi: 10.1371/journal.pone.0146721. eCollection 2016.

  PMID: 26766425 BACKGROUND

• Galbraith S, Daniel JA, Vissel B. A study of clustered data and approaches to its analysis. J Neurosci. 2010 Aug 11;30(32):10601-8. doi: 10.1523/JNEUROSCI.0362-10.2010.

  PMID: 20702692 BACKGROUND

• Aarts E, Verhage M, Veenvliet JV, Dolan CV, van der Sluis S. A solution to dependency: using multilevel analysis to accommodate nested data. Nat Neurosci. 2014 Apr;17(4):491-6. doi: 10.1038/nn.3648. Epub 2014 Mar 26.

  PMID: 24671065 BACKGROUND

• Zhang CH, Schwartz GG. Spatial Disparities in Coronavirus Incidence and Mortality in the United States: An Ecological Analysis as of May 2020. J Rural Health. 2020 Jun;36(3):433-445. doi: 10.1111/jrh.12476. Epub 2020 Jun 16.

  PMID: 32543763 BACKGROUND

• Theel ES, Slev P, Wheeler S, Couturier MR, Wong SJ, Kadkhoda K. The Role of Antibody Testing for SARS-CoV-2: Is There One? J Clin Microbiol. 2020 Jul 23;58(8):e00797-20. doi: 10.1128/JCM.00797-20. Print 2020 Jul 23.

  PMID: 32350047 BACKGROUND

• Buckley RM. Targeting the World's Slums as Fat Tails in the Distribution of COVID-19 Cases. J Urban Health. 2020 Jun;97(3):358-364. doi: 10.1007/s11524-020-00450-w.

  PMID: 32488763 BACKGROUND

Related Links

• Studies on the processes of social and urban integration in three Buenos Aires slums
• Participatory action research in health systems
• Systemic Facilitation of Collective Processes: Supporting Creativity and Participative Processes in Groups, Communities and Networks
• COVID-19 reagents
• Household and population census: villas 31 and 31 bis, City of Buenos Aires 2009
• The Color of Coronavirus: COVID-19 Deaths by Race and Ethnicity in the U.S.

MeSH Terms

Conditions

Coronavirus Infections

Condition Hierarchy (Ancestors)

Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections

Study Officials

• Alicia Mistchenko, MD PHD

  Hospital de Niños Ricardo Gutierrez

  PRINCIPAL INVESTIGATOR

• Vanina L Pagotto, MD MG

  Hospital Italiano de Buenos Aires

  STUDY CHAIR

• Silvana Figar, MD MG

  Hospital Italiano de Buenos Aires

  STUDY CHAIR

• Andrea Gamarnik, PHD

  National Council of Scientific and Technical Research, Argentina

  STUDY CHAIR

• Ana M Gomez Saldaño, MD MG

  Salud Comunitaria Ministerio de Salud GCBA

  STUDY CHAIR

• Fernan Quiroz, MD MG

  Ministerio de Salud GCBA

  STUDY DIRECTOR

• Lorena Luna, MG

  Salud Comunitaria Ministerio de Salud GCBA

  STUDY CHAIR

• Magdalena Wagner Manslau

  Salud Comunitaria Ministerio de Salud GCBA

  STUDY CHAIR

• Julieta Salto

  Salud Comunitaria Ministerio de Salud GCBA

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 12, 2020
• First Posted: July 15, 2020
• Study Start: June 10, 2020
• Primary Completion: June 26, 2020
• Study Completion: December 11, 2020
• Last Updated: December 17, 2020

Record last verified: 2020-12

Locations

AR (1)