NCT04463888

Brief Summary

In the proposed study, the investigators assumed that high dose of repetitive motor task training using an exoskeleton robot-assisted system may provide benefits in motor shaping and greater brain priming for hand paresis of the stroke patients. Nevertheless, the amount of therapeutic activity with clinicians' guidance is often short of number in therapy sessions.Therefore, using Internet of Things (IoT), connected rehabilitation products and the data they generate that are a new trend of rehabilitation strategy for providing remote home-programs support. The specific aim of this study is to to explore the feasibility of introducing the rental services of a Smart Home-based Exoskeleton Robot System through the IoT business model. And the second purpose is to investigate the effects of applying the exoskeleton robotic device for tenodesisgrip training as a home-based treatment for chronic stroke patients.The expected outcomes of this research are to clarify the feasibility of using IoT business model for launching smart rehabilitation device rental service and the effects of application a high dosage of hand movement training as home program on motor and hand function for patients with chronic stroke.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
18

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Aug 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 6, 2020

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 9, 2020

Completed
1 month until next milestone

Study Start

First participant enrolled

August 19, 2020

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2022

Completed
Last Updated

March 24, 2023

Status Verified

March 1, 2023

Enrollment Period

2.4 years

First QC Date

July 6, 2020

Last Update Submit

March 22, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in the result of Box and blocks test

    The score is the number of blocks carried from one box to the other in one minute. Higher values represent a better outcome.

    baseline, 4 weeks, 16 weeks and 20 weeks

Secondary Outcomes (5)

  • Change in the result of Fugl-Meyer assessment for UE motor function

    baseline, 4 weeks, 16 weeks and 20 weeks

  • Change in the result of Modified Ashworth scale (MAS)

    baseline, 4 weeks,16 weeks and 20 weeks

  • Change in the result of Semmes-Weinstein monofilament (SWM) test

    baseline, 4 weeks,16 weeks and 20 weeks

  • Change in the result of Motor Activity Log

    baseline, 4 weeks,16 weeks and 20 weeks

  • Clinical global impression scale

    post-intervention (week 4)

Study Arms (2)

Robot training with Smart Home-based Exoskeleton Robot System

EXPERIMENTAL

In addition to receiving hospital occupational therapy training twice a week, the participants will receive 60 minutes of home-based robot assisted tenodesis-grip training per day, 5 days a week, for 4 weeks .

Other: occupational therapy

control group

ACTIVE COMPARATOR

In addition to receiving hospital occupational therapy training twice a week, the participants will receive 60 minutes of home-based specific motor task training per day, 5 days a week, for 4 weeks .

Other: occupational therapy

Interventions

occupational therapy targeted to goals that are relevant to the functional needs of the patient

Robot training with Smart Home-based Exoskeleton Robot Systemcontrol group

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • (1) chronic stroke patients with unilateral cerebral infarction or hemorrhage, (2) computed tomography scan that excluded pathologies other than unilateral cerebral hemisphere injury, (3) capacity to perform a pinch task with the thumb and index finger, (4) no major cognitive or perceptual deficit (i.e., visual, auditory, perceptual, praxis, and memory, as determined using Lowenstein occupational therapy cognitive assessment), (5) premorbid right-handedness and (6) first-ever stroke.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Cheng-Kung University Hospital

Tainan, 704, Taiwan

Location

Related Publications (1)

  • Kuo LC, Yang KC, Lin YC, Lin YC, Yeh CH, Su FC, Hsu HY. Internet of Things (IoT) Enables Robot-Assisted Therapy as a Home Program for Training Upper Limb Functions in Chronic Stroke: A Randomized Control Crossover Study. Arch Phys Med Rehabil. 2023 Mar;104(3):363-371. doi: 10.1016/j.apmr.2022.08.976. Epub 2022 Sep 16.

MeSH Terms

Conditions

Stroke

Interventions

Occupational Therapy

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

RehabilitationAftercareContinuity of Patient CarePatient CareTherapeutics

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 6, 2020

First Posted

July 9, 2020

Study Start

August 19, 2020

Primary Completion

December 31, 2022

Study Completion

December 31, 2022

Last Updated

March 24, 2023

Record last verified: 2023-03

Locations