Acquired Syphlis by Non Sexual Contact

NCT04455425 | Completed

• 1 other identifier: Si non sexual
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always considered and must be ruled out by specialists in a careful evaluation. However, muco-cutaneous lesions can be a contagious source for congenital syphilis; therefore the possibility of non-sexual transmission through intimate contact with infected people through humid lesions (such as in kisses, breastfeeding, food-handling) or contaminated fomites (towels, bed sheets, underwear, cups, pacifiers, cutlery) could be considered. Experts worldwide have observed this non-sexual transmission, as described in many reports in literature. The investigators will study retrospectively patients from a cohort with non-sexual transmission. The diagnosis criteria used for acquired syphilis were as follows: age under 18 years with treponemic and nontreponemic positive tests, secondary-syphilis suspicious lesions and negative maternal syphilis serology. Nonsexual contagious was defined as contacts without physical and psychosocial indicators of sexual abuse according to current guides. In this cohort, in every case a psychosocial evaluation was completed with a written report in order to evaluate sexual contact probability. The teamo will describe these patients clinical and laboratory findings, family and close acquaintances serologies and probable source of contagious.

Conditions

Syphilis Acquired; Syphilis Infection

Outcome Measures

Primary Outcomes (3)

• Describe diagnose process of a cohort of children with assumed non-sexual acquired syphilis

  Describe the interdisciplinary approach of patients with acquired syphilis and how non-sexual transmission was assumed

  Past 20 years

• Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts

  Investigators will report serology titers from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening

  Past 20 years

• Describe reported symptoms and physical findings at diagnose and during follow-up f children with assumed non-sexual acquired syphilis and their close contacts

  Investigators will describe symptoms and physical findings from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening

  Past 20 years

Eligibility Criteria

• Age: 0 Years - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children from 0 to 18 years of age assisted at Parasitoloy and Chagas department from Children's Hospital in Buenos Aires, Argentina

You may qualify if:

• \- Children with treponemic and non-treponemic positive tests with primary or secondary-syphilis suspicious lesions

You may not qualify if:

• \- Children with diagnose criteria positive for Congenital syphilis

Sponsors & Collaborators

• Hospital de Niños R. Gutierrez de Buenos Aires: lead

Study Sites (1)

Hospital de Niños Ricardo Gutierrez

Buenos Aires, Buenos Aires F.D., 1425, Argentina

Location

Study Officials

• Guillermo Moscatelli, MD

  Principal Investigator

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 29, 2020
• First Posted: July 2, 2020
• Study Start: July 15, 2020
• Primary Completion: April 15, 2021
• Study Completion: May 15, 2021
• Last Updated: March 1, 2023

Record last verified: 2023-02

Locations

AR (1)