A Follow-up of the Influencing Factors of Dyskinesia in Patients With Parkinson's Disease

NCT04453995 | Unknown DMC

• 1 other identifier: XH-19-014
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson' patients who have not had dyskinesia would be observed for 2 years in a multicenter prospective study with the purposes to clarify the predicting factors of dyskinesia.

Conditions

Parkinson Disease; Dyskinesias

Keywords

Parkinson disease; Dyskinesia; follow up

Outcome Measures

Primary Outcomes (1)

• the occurrence of dyskinesia and its related predicting factors

  to evaluate the occurrence of dyskinesia during the 2 years of follow-up and identify its predicting factors of dyskinesia

  The data would be analyzed within 9 months of the study completion. The outcome would be reported within 1 year of the the study completion.

Secondary Outcomes (1)

• to evaluate patients ' living quality and the severity of non motor symptoms during the 2 years of follow-up

  The data would be analyzed within 9 months of the study completion. The outcome would be reported within 1 year of the the study completion.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

a 2 years prospective study to identify the predicting factors of dyskinesia in Parkinson' patients that have received Levodopa treatment.

You may qualify if:

• \- 1) Patients have been clinically diagnosed with Parkinson disease at the recruitment.
• \) Patients have received Levodopa treatment with the daily dosage above 200mg.

You may not qualify if:

• \) be suspicious of atypical Parkinson or other Parkinson syndrome. 2) have experienced dyskinesia. 3) incorporation to the investigation

Sponsors & Collaborators

• Xinhua Hospital, Shanghai Jiao Tong University School of Medicine: lead
• Shanghai Municipal Hospital of Traditional Chinese Medicine: collaborator
• Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University: collaborator
• Second Affiliated Hospital of Soochow University: collaborator
• The Affiliated BenQ Hospital of Nanjing Medical University: collaborator
• The Affiliated Hospital of Qingdao University: collaborator
• The First Affiliated Hospital with Nanjing Medical University: collaborator
• Zhejiang Provincial Tongde Hospital: collaborator
• Shaoxing Hospital of Traditional Chinese medicine: collaborator
• The First People Hospital of Hangzhou Lin An District: collaborator

Study Sites (1)

Xinhua hospital affiliated to Shanghai jiaotong university school of medicine

Shanghai, Shanghai Municipality, 200092, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

every participant would be request for provide 2 ml blood for extracting the DNA sample

MeSH Terms

Conditions

Parkinson Disease; Dyskinesias

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• zhenguo Liu, Ph.D.

  Xinhua hosipital affiliated to Shanghai Jiaotong university school of medicine

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 27, 2020
• First Posted: July 1, 2020
• Study Start: January 5, 2019
• Primary Completion: December 31, 2021
• Study Completion: June 1, 2022
• Last Updated: July 1, 2020

Record last verified: 2019-12

Locations

CN (1)