HbA1c as an Early Serologic Marker for the Hemodynamic Progression of Stage A Heart Failure

NCT04450576 | Unknown

• 1 other identifier: PIRB74
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

In a retrospective community based cohort study from Pueblo County Colorado which has a higher population proportion of metabolic syndrome and diabetes mellitus, we hope to clarify and quantify an association of the AGE HBa1c elevation with the early subclinical hemodynamic changes of diabetic cardiomyopathy as measured by LAV, LVM, E/A ratio, E/e' ratio and BNP in patients with stage A heart failure.

Conditions

Heart Failure, Diastolic

Outcome Measures

Primary Outcomes (1)

• Left Atrial volume

  Echocardiogram

  3 months

Secondary Outcomes (2)

• BNP

  3 months

• E/e'

  3 months

Interventions

Glycosylated hemoglobin DIAGNOSTIC_TEST

Glycosylated hemoglobin levels associated with correlative measures of diastolic cardiac function

Also known as: Echocardiogram

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Stage A heart failure patients who have had a Glycosylated hemoglobin, BNP and Echocardiogram with any 3 month contiguous time period during the lookback period

You may qualify if:

• Stage A heart failure on basis of metabolic criteria

You may not qualify if:

• LV dysfunction, valvular heart disease, hypertension and CAD

Sponsors & Collaborators

• Parkview Medical Center: lead

Study Sites (1)

Parkview Medical Center

Pueblo, Colorado, 81003, United States

Location

Related Publications (14)

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  PMID: 20117433 BACKGROUND

• Pueblo County 2016 Community Health Status report.

  BACKGROUND

MeSH Terms

Conditions

Heart Failure, Diastolic

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Heart Failure; Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Study Officials

• Doug Duffee, MD

  Parkview Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 25, 2020
• First Posted: June 29, 2020
• Study Start: December 20, 2019
• Primary Completion: October 30, 2020
• Study Completion: December 30, 2020
• Last Updated: November 16, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)