Nonthyroidal Illness Syndrome in SBS

NCT04450472 | Completed

• 1 other identifier: JinlingHospital
• Study Type: observational
• Target: 51
• Locations: 0 countries
• Sites: N/A

Brief Summary

Nonthyroidal illness syndrome (NTIS) is prevalent in critical illness; it is associated with poor outcomes. However, few studies have focused on the relationship between NTIS and short bowel syndrome (SBS). The aim of this study was to investigate the incidence, etiology, and prognosis of NTIS and its correlation in clinical variables in adult patients with SBS.

Conditions

Nonthyroidal Illness Syndrome; Short Bowel Syndrome

Outcome Measures

Primary Outcomes (1)

• Thyroid function index

  Thyroid function assessment includes level of free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxin (FT4), total thyroxin (TT4), thyroid stimulating hormone (TSH).

  Within one week of patients enrollment.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with SBS admitted to a clinical nutrition center in a tertiary referral hospital were identified to evaluate the incidence of NTIS and to explore its correlation with clinical variables and prognosis in adult patients.

You may qualify if:

• (1) Adult patients with SBS, defined as intestinal malabsorption disorder resulting from extensive bowel resection with a remnant small intestine length of greater than 200 cm, admitted to a clinical nutrition center.

You may not qualify if:

• age less than 18 years;
• previous history of thyroidal, hypophyseal or hypothalamic disease;
• lactational or gestational period;
• medication history of thyroidal hormone or antithyroid drugs;
• craniocerebral injury;
• attack of coronary heart disease, myocardial, or cerebral infarction in the past month;
• intracranial infection or hemorrhage in the past month. -

Sponsors & Collaborators

• Jinling Hospital, China: lead

MeSH Terms

Conditions

Short Bowel Syndrome

Condition Hierarchy (Ancestors)

Malabsorption Syndromes; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of the clinical nutrition center

Study Record Dates

• First Submitted: June 25, 2020
• First Posted: June 29, 2020
• Study Start: December 31, 2016
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: June 29, 2020

Record last verified: 2020-06