NCT04449822

Brief Summary

The study evaluates and compares effect of emergency surgery and colonic stents for treatment of malignant colonic obstructions.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at below P25 for not_applicable colorectal-cancer

Timeline
Completed

Started Jan 2017

Longer than P75 for not_applicable colorectal-cancer

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 5, 2017

Completed
3.5 years until next milestone

First Submitted

Initial submission to the registry

June 24, 2020

Completed
5 days until next milestone

First Posted

Study publicly available on registry

June 29, 2020

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 5, 2021

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 5, 2022

Completed
Last Updated

May 2, 2022

Status Verified

April 1, 2022

Enrollment Period

4.9 years

First QC Date

June 24, 2020

Last Update Submit

April 26, 2022

Conditions

Keywords

Hartmann's procedure, colostomy, colonic stenting.

Outcome Measures

Primary Outcomes (1)

  • The time of clinical relieve of obstruction

    24 hours after surgery/procedure

Secondary Outcomes (5)

  • Stent related complications

    time of hospital stay, an average 10 day.

  • Mortality

    30 day after surgery/procedure

  • Blood loss

    time of surgery/procedure

  • operation time

    during surgery/procedure

  • Overall complications

    30 day after surgery/procedure

Study Arms (2)

Emergency surgery

ACTIVE COMPARATOR

Surgical decompression with colostomy with or without resection and eventual re-anastomosis.

Procedure: Emergency surgery

Colonic stenting

ACTIVE COMPARATOR

The colonic stent placement

Procedure: Colonic stenting

Interventions

Surgical decompression with colostomy with or without resection and eventual re-anastomosis.

Emergency surgery

The colonic stent placement to relieve the colonic obstruction.

Colonic stenting

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patient with malignant colorectal obstructions.
  • Patient's approval to participate in the study.

You may not qualify if:

  • Patient's preference for either treatment method.
  • Patient's refusal to participate in the study.
  • Patients in the ASA group 4 and 5.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tbilisi State Medical University

Tbilisi, Yes, 0159, Georgia

Location

Related Publications (1)

  • Merabishvili G, Agdgomelashvili I, Mosidze B, Demetrashvili Z. Emergency surgery versus colorectal stenting for the management of left-sided malignant colon obstructions:A prospective cohort study. Acta Scientific Medical Sciences 2021, 5(4):18-23. doi: 10.31080/ASMS.2020.05.0863

    RESULT

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal Diseases

Study Officials

  • Zaza Demetrashvili

    Tbilisi State Medical University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Associate Professor, Surgery Department

Study Record Dates

First Submitted

June 24, 2020

First Posted

June 29, 2020

Study Start

January 5, 2017

Primary Completion

December 5, 2021

Study Completion

March 5, 2022

Last Updated

May 2, 2022

Record last verified: 2022-04

Locations