Normotensive and Hypertensive Placental Abruptions

NCT04449601 | Completed

• 1 other identifier: E52332816/49
• Study Type: observational
• Target: 115
• Locations: 0 countries
• Sites: N/A

Brief Summary

Placental abruption is a significant cause of both maternal morbidity and neonatal morbidity and mortality. Most abruptions accept to be related to a chronic placental disease process. Therefore, it is very important to understand these processes. To analyze maternal and neonatal effects of placental abruption(PA) through a novel classification in the presence of hypertension. Initial hemoglobin parameters were also compared to predict pregnancy outcomes in addition to hypertension.

Conditions

Abruptio Placentae; Affecting Fetus or Newborn

Keywords

Abruptio placenta; complete blood count; hypertension; perinatal outcome.; mean platelet volume

Outcome Measures

Primary Outcomes (1)

• blood pressure measurement

  mm Hg

  2 minute

Secondary Outcomes (3)

• hemogram parameters WBC(white blood cell) ,PLT(Platelet), MPV(mean platelet volume), HGB(hemoglobin), Neutrophil lymphocyte ratio..)

  first 1 hour

• maternal and newborn length, weight

  5 minute

• APGAR score

  5 minute

Study Arms (2)

Group 1 (with hypertension )

Two groups were classified regarding of presence or absence of hypertension (53 hypertensive, 62 normotensive).

Other: clinical assesment

Group 2( without hypertension)

Two groups were classified regarding of presence or absence of hypertension (53 hypertensive, 62 normotensive).

Other: clinical assesment

Interventions

clinical assesment OTHER

Comparison of Hypertensive group and normotensive group

Group 1 (with hypertension ); Group 2( without hypertension)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Two groups were formed according to presence or absence of hypertension (53 hypertensive, 62 normotensive) who has placental abruption.

You may qualify if:

• spontaneous,
• singleton pregnancies
• above 25 weeks of gestations with positive fetal cardiac activity

You may not qualify if:

• multiple gestations,
• presence of fetal or maternal infection,
• chronic inflammatory diseases or connective tissue disorders
• history of myocardial infarction,
• thrombosis
• history of steroid drug usage.

Sponsors & Collaborators

• Hatice Akkaya: lead

MeSH Terms

Conditions

Abruptio Placentae; Hypertension

Condition Hierarchy (Ancestors)

Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Placenta Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Hatice Akkaya, Ass Prof

  Kayseri Education and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: June 20, 2020
• First Posted: June 29, 2020
• Study Start: January 1, 2016
• Primary Completion: April 30, 2017
• Study Completion: November 30, 2017
• Last Updated: June 29, 2020

Record last verified: 2020-06

Data Sharing

• IPD Sharing: Will not share