Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy
1 other identifier
observational
100
1 country
1
Brief Summary
The purpose of this study is to detecte and predict early subclinical cardiac damage induced by thoracic radiation therapy based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2020
CompletedFirst Submitted
Initial submission to the registry
June 21, 2020
CompletedFirst Posted
Study publicly available on registry
June 23, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2021
CompletedJune 23, 2020
June 1, 2020
2 years
June 21, 2020
June 21, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy
To detecte early subclinical cardiac damage induced by thoracic radiation therapy, based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers
2020-2021
Eligibility Criteria
patients with thoracic radiotherapy
You may qualify if:
- with malignant tumors
- will receive radiotherapy
- with cardiac exposure during the radiotherapy process
- could receive regular follow-up for 12 months
- written informed consent
You may not qualify if:
- satisfactory echocardiographic images could not be obtained
- moderate or severe valvular disease
- cardiomyopathy
- congenital heart disease
- refractory hypertension
- coronary artery disease\*
- heart failure
- arrhythmia requiring intervention
- pericarditis
- acute myocarditis
- participating in other clinical studies of drug intervention
- severe liver and kidney dysfunction
- autoimmune disease
- pulmonary hypertension
- coronary artery disease: at least 50% stenosis besed on previous coronary angiography or CTA, or with a history of percutaneous coronary stent implantation.
- +1 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
Related Publications (2)
Li T, Zhuang H, Wang Y, Li J, Zhu D, Cui M. Two-dimensional speckle tracking echocardiography in evaluating radiation-induced heart damage. Asia Pac J Oncol Nurs. 2021 Dec 25;9(2):119-124. doi: 10.1016/j.apjon.2021.12.008. eCollection 2022 Feb.
PMID: 35529415DERIVEDZhu D, Li T, Zhuang H, Cui M. Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy: Study Protocol for a Prospective Cohort Study. Front Cardiovasc Med. 2022 Jan 26;8:735265. doi: 10.3389/fcvm.2021.735265. eCollection 2021.
PMID: 35155592DERIVED
Biospecimen
blood samples will be collected
Study Officials
- STUDY DIRECTOR
Dan Zhu
Peking University Third Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 12 Months
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 21, 2020
First Posted
June 23, 2020
Study Start
January 1, 2020
Primary Completion
December 31, 2021
Study Completion
December 31, 2021
Last Updated
June 23, 2020
Record last verified: 2020-06