Curcuma Extract Beneficial for Muscle Damage

NCT04439981 | Completed DMC

• 1 other identifier: Curcuma
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Muscle damage and inflammation is a clinical problem caused by the unimpeachable body adaptation of strenuous exercise through increasing free radicals. Antioxidants content in Curcuma is hypothesized to alleviate the free radicals. This study aimed to examine the effect of Curcuma extract in the form of ice cream to improve muscle damage and inflammation of soccer athletes caused by strenuous exercise. This study was experimental study with pre-post control group design. Male soccer athlete (n=20) were divided into treatment group (n=10) and control group (n=10). The treatment group was treated by Curcuma extract ice cream for 21 days. Blood samples of creatine kinase (as muscle damage marker) and IL-6 (as inflammation marker) were quantified.

Conditions

Athletes Foot

Keywords

Curcuma extract; ice cream; inflammation; muscle damage

Outcome Measures

Primary Outcomes (4)

• Lactic acid change

  Change from baseline lactic acid at 21 days taken in the lab from venous blood specimen using spectrophotometric method

  21 days

• Hemoglobin change

  Change from baseline hemoglobin at 21 days taken in the lab from venous blood specimen using cyanmethemoglobin method

  21 days

• IL-6 change

  Change from baseline IL-6 at 21 days taken in the lab from venous blood specimen using ELISA method

  21 days

• Creatinine kinase change

  Change from baseline creatinine kinase at 21 days taken in the lab from venous blood specimen using ELISA method

  21 days

Study Arms (2)

Control Group

PLACEBO COMPARATOR

treated by ice cream without any Curcuma extract supplementation

Dietary Supplement: Ice cream

Treatment Group

EXPERIMENTAL

treated by ice cream supplemented by Curcuma extract

Dietary Supplement: Ice cream

Interventions

Ice cream DIETARY_SUPPLEMENT

Curcumin extract was added into ice cream

Control Group; Treatment Group

Eligibility Criteria

• Age: 14 Years - 18 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• male
• year-old
• does not have an acute and chronic
• hemoglobin level ≥13 g/L
• nutrition status normal (BMI \>18.5-25.0)
• no coffee consumption
• no alcohol consumption
• no drugs consumption
• no smoking
• no vitamin and other supplements consumption at least two weeks before this study was conducted
• no additional exercise except the programmed exercise

You may not qualify if:

• Subject did not comply the procedure of the study

Sponsors & Collaborators

• Universitas Muhammadiyah Semarang: lead

Study Sites (1)

Badan Pusat Pendidikan dan Pelatihan Olahraga Pelajar (BPPLOP) Semarang, Indonesia

Semarang, Provinsi, 50198, Indonesia

Location

MeSH Terms

Conditions

Tinea Pedis; Inflammation

Interventions

Ice Cream

Condition Hierarchy (Ancestors)

Tinea; Dermatomycoses; Mycoses; Bacterial Infections and Mycoses; Infections; Skin Diseases, Infectious; Foot Dermatoses; Foot Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Pruritus; Skin Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Intervention Hierarchy (Ancestors)

Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Ali Rosidi, Doctor

  Universitas Muhammadiyah Semarang

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dean of Faculty of Nursing and Health, Universitas Muhammadiyah Semarang

Model Details: Subjects were divided by 2 groups: control group (n=10), treated by ice cream without any Curcuma extract supplementation; and treatment group (n=10), treated by ice cream supplemented by Curcuma extract.

Study Record Dates

• First Submitted: June 11, 2020
• First Posted: June 19, 2020
• Study Start: April 8, 2019
• Primary Completion: July 8, 2019
• Study Completion: July 29, 2019
• Last Updated: June 19, 2020

Record last verified: 2020-06

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)