Software Application for Low-Sodium Diet Trial (SALT)

NCT04438551 | Withdrawn

• 1 other identifier: 4979
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This a single-center prospective randomized controlled trial. Subjects will be assigned to the standard of care dietary recommendations for a low sodium diet (LSD) vs. the standard of care dietary recommendations for a low sodium diet plus a mobile application that analyzes sodium content of shopping lists that are created prior to shopping trips to the grocery store over an 8-week study period. An initial pilot phase will be done to ensure adequate percentage of subjects are completing the study in the intervention group and that adequate data is being collected.

Conditions

Kidney Stone; Hypernatriuria

Keywords

Kidney stone; Low sodium diet; Mobile health app; Stone prevention; Behavioral modification

Outcome Measures

Primary Outcomes (2)

• Mean change in score of Knowledge of Low Sodium Diet Questionnaire

  Subjects will complete a low sodium diet validated questionnaire, score range from 0 to 26, higher score indicates better knowledge of role of sodium in diet and relationship of sodium to certain foods.

  Baseline to 8 weeks

• Mean change in twenty four hour urinary sodium levels

  Urinary sodium levels measured by collecting two 24-hour urine samples at pre-study and 8 weeks. The two 24-hr samples will be averaged to get a single urinary sodium level at each time point, the change will be recorded for each subject and the mean and standard deviation for the intervention and control groups will be compared

  Baseline to 8 weeks

Secondary Outcomes (2)

• Exploratory within-group assessment of application usage in the intervention group

  Baseline to 8 weeks

• Exploratory within-group assessment of application usage in the intervention group

  Baseline to 8 weeks

Other Outcomes (1)

• Pilot phase - Percent of subjects using the application

  8 weeks

Study Arms (2)

Standard dietary counseling

ACTIVE COMPARATOR

Subjects will be given the standard low sodium diet handout with counseling, complete a validated low sodium questionnaire, and a 24-hr urine collection.

Behavioral: Standard dietary counseling

Standard dietary counseling plus mobile app

EXPERIMENTAL

Subjects will be given the standard low sodium diet handout with counseling, complete a validated low sodium questionnaire, and a 24-hr urine collection. Subjects will use a mobile app to build their shopping lists prior to grocery shopping.

Behavioral: Standard dietary counseling; Behavioral: Mobile app

Interventions

Standard dietary counseling BEHAVIORAL

Subjects will be given a low sodium diet handout with counseling, complete a validated questionnaire on low sodium foods, and complete a 24-hr urine collection.

Standard dietary counseling; Standard dietary counseling plus mobile app

Mobile app BEHAVIORAL

Subjects will be given a low sodium diet handout with counseling, complete a validated questionnaire on low sodium foods, and complete a 24-hr urine collection. Subjects will be given a mobile app to build grocery lists where the sodium level will be recorded and tracked in the app.

Standard dietary counseling plus mobile app

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male and female adults aged 18 or greater and any race/ethnicity
• Diagnosis of Kidney Stone Disease (KSD) within previous 6 months via:
• Surgical procedure for KSD -- OR
• Imaging demonstrating KSD (abdominal xray or CT scan)
• Diagnosis of hypernatriuria (elevated urinary sodium \>150mmol/d) on 24-hour urine collection within previous 6 months
• Mobile phone with iOS
• Working email address
• Food purchased at Wegmans grocery stores in the Rochester area during the study period
• Willingness to participate and able to provide informed consent

You may not qualify if:

• Pregnancy
• Current use of medications prescribed for prevention of KSD
• Current prescription of low sodium diet due to another medical condition
• Inability or unwillingness to use mobile application
• Do not participate in grocery shopping

Sponsors & Collaborators

• University of Rochester: lead

Study Sites (1)

University of Rochester

Rochester, New York, 14642, United States

Location

Related Publications (18)

• Pearle MS, Goldfarb DS, Assimos DG, Curhan G, Denu-Ciocca CJ, Matlaga BR, Monga M, Penniston KL, Preminger GM, Turk TM, White JR; American Urological Assocation. Medical management of kidney stones: AUA guideline. J Urol. 2014 Aug;192(2):316-24. doi: 10.1016/j.juro.2014.05.006. Epub 2014 May 20.

  PMID: 24857648 BACKGROUND

• Friedlander JI, Antonelli JA, Pearle MS. Diet: from food to stone. World J Urol. 2015 Feb;33(2):179-85. doi: 10.1007/s00345-014-1344-z. Epub 2014 Jun 18.

  PMID: 24938177 BACKGROUND

• Penniston KL. The nutrition consult for recurrent stone formers. Curr Urol Rep. 2015 Jul;16(7):47. doi: 10.1007/s11934-015-0518-6.

  PMID: 26025494 BACKGROUND

• Wertheim ML, Nakada SY, Penniston KL. Current practice patterns of urologists providing nutrition recommendations to patients with kidney stones. J Endourol. 2014 Sep;28(9):1127-31. doi: 10.1089/end.2014.0164. Epub 2014 Jun 30.

  PMID: 24846196 BACKGROUND

• Kitchin B. Nutrition counseling for patients with osteoporosis: a personal approach. J Clin Densitom. 2013 Oct-Dec;16(4):426-31. doi: 10.1016/j.jocd.2013.08.013. Epub 2013 Sep 25.

  PMID: 24075239 BACKGROUND

• Ravasco P, Monteiro-Grillo I, Camilo M. Individualized nutrition intervention is of major benefit to colorectal cancer patients: long-term follow-up of a randomized controlled trial of nutritional therapy. Am J Clin Nutr. 2012 Dec;96(6):1346-53. doi: 10.3945/ajcn.111.018838. Epub 2012 Nov 7.

  PMID: 23134880 BACKGROUND

• Franz MJ, Boucher JL, Evert AB. Evidence-based diabetes nutrition therapy recommendations are effective: the key is individualization. Diabetes Metab Syndr Obes. 2014 Feb 24;7:65-72. doi: 10.2147/DMSO.S45140. eCollection 2014.

  PMID: 24591844 BACKGROUND

• Galdas P, Fell J, Bower P, Kidd L, Blickem C, McPherson K, Hunt K, Gilbody S, Richardson G. The effectiveness of self-management support interventions for men with long-term conditions: a systematic review and meta-analysis. BMJ Open. 2015 Mar 20;5(3):e006620. doi: 10.1136/bmjopen-2014-006620.

  PMID: 25795688 BACKGROUND

• Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013 Jun 26;2013:129841. doi: 10.1155/2013/129841. Print 2013.

  PMID: 23878520 BACKGROUND

• Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, Dellavalle R, Danaei G, Ezzati M, Fahimi A, Flaxman D, Foreman, Gabriel S, Gakidou E, Kassebaum N, Khatibzadeh S, Lim S, Lipshultz SE, London S, Lopez, MacIntyre MF, Mokdad AH, Moran A, Moran AE, Mozaffarian D, Murphy T, Naghavi M, Pope C, Roberts T, Salomon J, Schwebel DC, Shahraz S, Sleet DA, Murray, Abraham J, Ali MK, Atkinson C, Bartels DH, Bhalla K, Birbeck G, Burstein R, Chen H, Criqui MH, Dahodwala, Jarlais, Ding EL, Dorsey ER, Ebel BE, Ezzati M, Fahami, Flaxman S, Flaxman AD, Gonzalez-Medina D, Grant B, Hagan H, Hoffman H, Kassebaum N, Khatibzadeh S, Leasher JL, Lin J, Lipshultz SE, Lozano R, Lu Y, Mallinger L, McDermott MM, Micha R, Miller TR, Mokdad AA, Mokdad AH, Mozaffarian D, Naghavi M, Narayan KM, Omer SB, Pelizzari PM, Phillips D, Ranganathan D, Rivara FP, Roberts T, Sampson U, Sanman E, Sapkota A, Schwebel DC, Sharaz S, Shivakoti R, Singh GM, Singh D, Tavakkoli M, Towbin JA, Wilkinson JD, Zabetian A, Murray, Abraham J, Ali MK, Alvardo M, Atkinson C, Baddour LM, Benjamin EJ, Bhalla K, Birbeck G, Bolliger I, Burstein R, Carnahan E, Chou D, Chugh SS, Cohen A, Colson KE, Cooper LT, Couser W, Criqui MH, Dabhadkar KC, Dellavalle RP, Jarlais, Dicker D, Dorsey ER, Duber H, Ebel BE, Engell RE, Ezzati M, Felson DT, Finucane MM, Flaxman S, Flaxman AD, Fleming T, Foreman, Forouzanfar MH, Freedman G, Freeman MK, Gakidou E, Gillum RF, Gonzalez-Medina D, Gosselin R, Gutierrez HR, Hagan H, Havmoeller R, Hoffman H, Jacobsen KH, James SL, Jasrasaria R, Jayarman S, Johns N, Kassebaum N, Khatibzadeh S, Lan Q, Leasher JL, Lim S, Lipshultz SE, London S, Lopez, Lozano R, Lu Y, Mallinger L, Meltzer M, Mensah GA, Michaud C, Miller TR, Mock C, Moffitt TE, Mokdad AA, Mokdad AH, Moran A, Naghavi M, Narayan KM, Nelson RG, Olives C, Omer SB, Ortblad K, Ostro B, Pelizzari PM, Phillips D, Raju M, Razavi H, Ritz B, Roberts T, Sacco RL, Salomon J, Sampson U, Schwebel DC, Shahraz S, Shibuya K, Silberberg D, Singh JA, Steenland K, Taylor JA, Thurston GD, Vavilala MS, Vos T, Wagner GR, Weinstock MA, Weisskopf MG, Wulf S, Murray; U.S. Burden of Disease Collaborators. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA. 2013 Aug 14;310(6):591-608. doi: 10.1001/jama.2013.13805.

  PMID: 23842577 BACKGROUND

• Slawson DL, Fitzgerald N, Morgan KT. Position of the Academy of Nutrition and Dietetics: the role of nutrition in health promotion and chronic disease prevention. J Acad Nutr Diet. 2013 Jul;113(7):972-9. doi: 10.1016/j.jand.2013.05.005.

  PMID: 23790411 BACKGROUND

• Hall AK, Cole-Lewis H, Bernhardt JM. Mobile text messaging for health: a systematic review of reviews. Annu Rev Public Health. 2015 Mar 18;36:393-415. doi: 10.1146/annurev-publhealth-031914-122855.

  PMID: 25785892 BACKGROUND

• Free C, Phillips G, Watson L, Galli L, Felix L, Edwards P, Patel V, Haines A. The effectiveness of mobile-health technologies to improve health care service delivery processes: a systematic review and meta-analysis. PLoS Med. 2013;10(1):e1001363. doi: 10.1371/journal.pmed.1001363. Epub 2013 Jan 15.

  PMID: 23458994 BACKGROUND

• Eyles H, McLean R, Neal B, Jiang Y, Doughty RN, McLean R, Ni Mhurchu C. A salt-reduction smartphone app supports lower-salt food purchases for people with cardiovascular disease: Findings from the SaltSwitch randomised controlled trial. Eur J Prev Cardiol. 2017 Sep;24(13):1435-1444. doi: 10.1177/2047487317715713. Epub 2017 Jun 20.

  PMID: 28631933 BACKGROUND

• Sarmugam R, Worsley A, Flood V. Development and validation of a salt knowledge questionnaire. Public Health Nutr. 2014 May;17(5):1061-8. doi: 10.1017/S1368980013000517. Epub 2013 Mar 18.

  PMID: 23507427 BACKGROUND

• Claro RM, Linders H, Ricardo CZ, Legetic B, Campbell NR. Consumer attitudes, knowledge, and behavior related to salt consumption in sentinel countries of the Americas. Rev Panam Salud Publica. 2012 Oct;32(4):265-73. doi: 10.1590/s1020-49892012001000004.

  PMID: 23299287 BACKGROUND

• Cook NR, Cutler JA, Obarzanek E, Buring JE, Rexrode KM, Kumanyika SK, Appel LJ, Whelton PK. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ. 2007 Apr 28;334(7599):885-8. doi: 10.1136/bmj.39147.604896.55. Epub 2007 Apr 20.

  PMID: 17449506 BACKGROUND

• Dorsch MP, An LC, Hummel SL. A Novel Just-in-Time Contextual Mobile App Intervention to Reduce Sodium Intake in Hypertension: Protocol and Rationale for a Randomized Controlled Trial (LowSalt4Life Trial). JMIR Res Protoc. 2018 Dec 7;7(12):e11282. doi: 10.2196/11282.

  PMID: 30530462 BACKGROUND

MeSH Terms

Conditions

Kidney Calculi

Condition Hierarchy (Ancestors)

Nephrolithiasis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Rajat Jain, MD

  University of Rochester

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Single-center prospective randomized controlled trial

Study Record Dates

• First Submitted: June 16, 2020
• First Posted: June 19, 2020
• Study Start: February 12, 2021
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: August 16, 2023

Record last verified: 2023-08

Locations

US (1)