Network-Targeted Strategies for Efficient Community SARS-CoV-2 (COVID-19) Sampling

NCT04437706 | Completed

• 1 other identifier: Pro00105430
• Study Type: observational
• Target: 602
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective is to use "network targeted sampling design" to detect active and/or undiagnosed cases of COVID-19 in the community and determine the spread or distribution of 1) active infection, and 2) past exposure. The hypothesis is that there are many undiagnosed and/or asymptomatic people in the community who may be unknowingly spreading the virus or have been exposed and have antibodies. We propose to implement respondent-driven sampling (RDS) which leverages effort on the part of seed or index cases to recruit contacts for participation.

Conditions

COVID-19; SARS-CoV 2

Keywords

network analysis; contact tracing; respondent driven sampling

Outcome Measures

Primary Outcomes (2)

• Number of Participants with Active Infection

  Number of participants with active COVID-19 infection

  12 months

• Number of Participants with Antibodies Indicating Past Exposure

  Number of participants with antibodies indicating past exposure to SARS-CoV-2

  12 months

Study Arms (1)

Participants

Participants completing COVID-19 testing

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults (18+ years) in the community who have tested positive for COVID-19 or have been in close contact with someone who is known to be COVID-19 positive

You may qualify if:

• Positive COVID-19 test result -or- receipt of a coupon from a previous study participant
• Resident of Durham County (for seed participant only)
• Willing to undergo COVID-19 test nasopharyngeal swab for RT-PCR testing and blood draw for COVID-19 antibody testing
• Age 18+
• Speak and understand English

You may not qualify if:

• Currently receiving inpatient treatment for COVID-19
• Unable to consent

Sponsors & Collaborators

• Duke University: lead

Study Sites (1)

Margaret Pendzich

Durham, North Carolina, 27710, United States

Location

Related Publications (2)

• Pasquale DK, Welsh W, Olson A, Yacoub M, Moody J, Barajas Gomez BA, Bentley-Edwards KL, McCall J, Solis-Guzman ML, Dunn JP, Woods CW, Petzold EA, Bowie AC, Singh K, Huang ES. Scalable Strategies to Increase Efficiency and Augment Public Health Activities During Epidemic Peaks. J Public Health Manag Pract. 2023 Nov-Dec 01;29(6):863-873. doi: 10.1097/PHH.0000000000001780. Epub 2023 Jun 28.

  PMID: 37379511 RESULT

• Pasquale DK, Welsh W, Bentley-Edwards KL, Olson A, Wellons MC, Moody J. Homophily and social mixing in a small community: Implications for infectious disease transmission. PLoS One. 2024 May 28;19(5):e0303677. doi: 10.1371/journal.pone.0303677. eCollection 2024.

  PMID: 38805519 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Blood and pharyngeal swabs

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Dana Pasquale, PhD

  Duke University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 17, 2020
• First Posted: June 18, 2020
• Study Start: December 11, 2020
• Primary Completion: July 25, 2022
• Study Completion: July 25, 2022
• Last Updated: June 6, 2024

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)