INTER-Regional COHORTE of Long Term Pancreatic Cancer Survivors

NCT04436679 | Completed

• 2 other identifiers: 2019_292019-A02001-56
• Study Type: observational
• Target: 342
• Locations: 1 country
• Sites: 1

Brief Summary

The study is particularly innovative as it will accurately analyze the microscopic characteristics of the stroma, tumor budding and mucin expression in adenocarcinomas of the pancreas, using a comparative approach of long-survivor/short-survival patients.

Conditions

Pancreas Cancer; Pancreatic Adenocarcinoma

Keywords

survival; prognosis; tissue; pancreas cancer

Outcome Measures

Primary Outcomes (1)

• Relationship between known prognostic histological markers of pancreatic adenocarcinoma and patient survival.

  Tissue analysis will be performed by conventional microscopy and will evaluate histological markers known in the literature to have a prognostic impact.

  at 2 years

Secondary Outcomes (1)

• Relationship between newly described histological markers for pancreatic adenocarcinoma and patient survival.

  at 2 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pancreatic adenocarcinoma patients operated on between 2001 and 2016.

You may qualify if:

• Patients \> 18 years of age at diagnosis
• Primary pancreatic cancer patients operated on in one of the 4 centres between 2001 and 2016
• Histopathological diagnosis of excreto-pancreatic adenocarcinoma of the pancreas, ductal adenocarcinoma or classical adenocarcinoma
• Tissue blocks (FFPE) available (tumour/healthy tissue)
• Affiliated to a social security scheme

You may not qualify if:

• Absence of Primary Cancer Tissue Blocks (PCTBs)
• Paraffin block fixed in Bouin or AFA
• Patient Refusal
• Pancreatic cancer not corresponding to a conventional excretopancreatic adenocarcinoma such as: carcinoma on intraductal papillary mucinous neoplasm, endocrine tumor/carcinoma, acinar cell carcinoma, ...).
• Patient died due to post-surgical complications (death within 30 days post-surgery).
• Surgical resection of macroscopic R2 type.

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hop Claude Huriez Chu Lille

Lille, 59037, France

Location

Biospecimen

Retention: SAMPLES WITH DNA

tissues paraffin lumbered paraffin blocks of tissue-microarrays

MeSH Terms

Conditions

Pancreatic Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Study Officials

• Emmanuelle Leteurtre, MD,PhD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 15, 2020
• First Posted: June 18, 2020
• Study Start: February 2, 2021
• Primary Completion: February 22, 2025
• Study Completion: February 22, 2025
• Last Updated: March 30, 2025

Record last verified: 2025-03

Locations

FR (1)