NCT04433000

Brief Summary

Ultrasound imaging of the lung (LUS) and associated tissues has demonstrated clinical utility in COVID-19 patients. The aim of the present study was to evaluate the possibilities of a portable pocket-sized ultrasound scanner in the evaluation of lung involvement in patients with COVID-19 pneumonia, in comparison with a high end ultrasound scanner. Statisical analysis will be performed with Stata for Windows V 16 (Stata corp, Texas College, TX). Power size estimation using Medcalc 19.3.1, (MedCalc Software Ltd, Ostenda, B) showed that hat 34 patients would be required for the comparison of the two methods using the Bland-Altman method assuming a mean difference in total score of 1±1, a false positive rate (α) of 0.05 and a false negative rate of 0.1 (β=0.9).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
34

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Mar 2020

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 15, 2020

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 10, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 10, 2020

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

June 12, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

June 16, 2020

Completed
Last Updated

June 16, 2020

Status Verified

June 1, 2020

Enrollment Period

3 months

First QC Date

June 12, 2020

Last Update Submit

June 13, 2020

Conditions

Keywords

Covid-19pneumonialung ultrasound

Outcome Measures

Primary Outcomes (1)

  • Bland-Altman estimate of bias and Limits of Agreement (LoA) of patient mean scores obtained with the two instruments

    The more widely accepted measure of agreement beteen two instruments. Bland JM, Altman DG (1986) Statistical method for assessing agreement between two methods of clinical measurement. The Lancet i:307-310

    1 day

Interventions

ButterflyDIAGNOSTIC_TEST

Standardized lung ultrasound scan with two different instruments

Also known as: GE Healthcare Venue GO

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients admitted to hospital ward with a diagnosis of Covid-19 preumonia, confirmed by a positive rtPCR swab and radiography

You may qualify if:

  • Admitted to hospital ward with a diagnosis of Covid-19 preumonia, confirmed by a positive rtPCR swab and radiography

You may not qualify if:

  • Unable/unwilling to cooperate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Azienda Ospedaliera Universitaria Senese

Siena, Si, 53100, Italy

RECRUITING

MeSH Terms

Conditions

COVID-19Pneumonia

Condition Hierarchy (Ancestors)

Pneumonia, ViralRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Officials

  • David Bennett, MD

    Azienda Ospedaliera Universitaria Senese

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Piersante Sestini, MD

CONTACT

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate professor of respiratory diseases

Study Record Dates

First Submitted

June 12, 2020

First Posted

June 16, 2020

Study Start

March 15, 2020

Primary Completion

June 10, 2020

Study Completion

June 10, 2020

Last Updated

June 16, 2020

Record last verified: 2020-06

Data Sharing

IPD Sharing
Will share

The whole anonymized dataset could be shared

Shared Documents
STUDY PROTOCOL
Time Frame
from the month of July, for one year
Access Criteria
on request by email

Locations