Seroconversion Among Staff at a Large Acute Care Hospital in Denmark During the COVID-19 Pandemic
1 other identifier
observational
300
1 country
2
Brief Summary
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in samples collected from HCWs in an acute hospital. This will enable the identification of those who are protected and non-infectious for SARS-CoV2 and those who are seronegative and therefore potentially susceptible and infectious on patient contact. Prospective testing will provide data on the acquisition of SARS-CoV2 infections among HCWs and associated risk factors for transmission during a pandemic at an acute care hospital facility in the capital region of Denmark. Hypothesis: Serial seroconversion measurements in hospital employees improve the organization of the clinical treatment and care during the COVID-19 pandemic at Nordsjællands Hospital and Nykøbing Falster County Hospital.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2020
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 27, 2020
CompletedFirst Submitted
Initial submission to the registry
May 11, 2020
CompletedFirst Posted
Study publicly available on registry
June 16, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2025
CompletedJune 16, 2020
June 1, 2020
5.4 years
May 11, 2020
June 12, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Serology testing for specific COVID-19
IgM and IgG (Covid-19 antibodies)
From baseline to follow up at four years
Secondary Outcomes (1)
SARS-CoV-2 infection
From baseline to follow up at three months
Other Outcomes (1)
Co-variates
At baseline
Study Arms (1)
Serial seroconversion measurements in hospital employees
Serial seroconversion measurements in hospital employees during the COVID-19 pandemic
Interventions
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in samples collected from HCWs in an acute hospital.
Eligibility Criteria
Health care workers at two Danish hospitals
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Nordsjaellands Hospitallead
- University of Oxfordcollaborator
- Nykøbing Falster County Hospitalcollaborator
Study Sites (2)
Nordsjællands Hospital
Hillerød, Capital Region, 3400, Denmark
Nykøbing Falster County Hospital
Nykøbing Falster, Southern Region, 4800, Denmark
Biospecimen
Full blood samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Thea K Fischer, professor
Nordsjaellands Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
May 11, 2020
First Posted
June 16, 2020
Study Start
March 27, 2020
Primary Completion
August 1, 2025
Study Completion
August 1, 2025
Last Updated
June 16, 2020
Record last verified: 2020-06