NCT04427878

Brief Summary

Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Aug 2020

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 10, 2020

Completed
1 day until next milestone

First Posted

Study publicly available on registry

June 11, 2020

Completed
2 months until next milestone

Study Start

First participant enrolled

August 3, 2020

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 9, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 9, 2020

Completed
Last Updated

June 27, 2024

Status Verified

November 1, 2023

Enrollment Period

1 month

First QC Date

June 10, 2020

Last Update Submit

June 26, 2024

Conditions

Covid-19 Patients

Outcome Measures

Primary Outcomes (1)

  • The presence of SARS-CoV2 in adipose tissue of Covid19 patients

    RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection

    Day 0

Secondary Outcomes (3)

  • The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    Day 0

  • The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    Day 0

  • The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    Day 0

Study Arms (1)

patients with Covid-19

EXPERIMENTAL
Procedure: biopsies of subcutaneous adipose tissue

Interventions

biopsies of subcutaneous adipose tissuePROCEDURE

Two 4mm punch biopsies of subcutaneous abdominal or thight adipose tissue

patients with Covid-19

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male or female ≥ 18 years old
  • Patients testing positive for Covid19
  • Patients affiliated to social security
  • Signing of free and informed consent

You may not qualify if:

  • Vulnerable persons (- minors,
  • adults under guardianship or curatorship,
  • pregnant women,
  • persons deprived of their liberty,
  • persons who do not master the French language)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Nice

Nice, 06000, France

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 10, 2020

First Posted

June 11, 2020

Study Start

August 3, 2020

Primary Completion

September 9, 2020

Study Completion

September 9, 2020

Last Updated

June 27, 2024

Record last verified: 2023-11

Locations

FR(1)