A New Anatomical Classification of Portal Vein Location of Pancreas Tumors

NCT04416685 | Completed

• 1 other identifier: PVR-2019
• Study Type: interventional
• Target: 43
• Locations: 0 countries
• Sites: N/A

Brief Summary

In this retrospective study, we recorded the location of pancreatic tumors and relation/proximity to the portal vein. The surgical difficulty and requirement of additional interventions were also evaluated.

Conditions

Pancreatic Neoplasm Malignant Head Primary

Keywords

pancreas tumors

Outcome Measures

Primary Outcomes (1)

• peri-operative or postoperative complication

  surgical complications observed during both operative and postoperative period

  up to one month

Secondary Outcomes (1)

• hospital stay

  up to one month

Other Outcomes (1)

• in hospital mortality

  up to two months

Study Arms (3)

Level 1

OTHER

Those tumors located superior to the portal confluence were classified as Level I,

Procedure: primary repair; Procedure: segmental resection

Level II

OTHER

those tumors located on the confluence (involving the confluence) located on the portal confluence

Procedure: primary repair; Procedure: segmental resection

Level III

OTHER

those tumors located inferior to the portal confluence

Procedure: segmental resection; Procedure: graft reconstruction

Interventions

primary repair PROCEDURE

For Level I-II tumors, in case of segmental resection of PV/SMV, the reconstruction was performed by an end-to-end anastomosis either by direct suture (for defect under 2 cm) or by using an interposition venous or prosthetic graft. For this purpose, autologous grafting we used internal jugular vein and cadaveric iliac vein and alternatively, synthetic PTFE graft was also used.

Level 1; Level II

segmental resection PROCEDURE

For Level I-II tumors, in case of segmental resection of PV/SMV, the reconstruction was performed by an end-to-end anastomosis either by direct suture (for defect under 2 cm) or by using an interposition venous or prosthetic graft. For this purpose, autologous grafting we used internal jugular vein and cadaveric iliac vein and alternatively, synthetic PTFE graft was also used.

Also known as: primary repair

Level 1; Level II; Level III

graft reconstruction PROCEDURE

Regarding Level III tumors, complete resection of the tumor was done either by tangential excision or by partial venous excision and subsequent reconstruction. To maintain a secure anastomosis, the mesenteric root was mobilized completely or/and splenic vein was divided.

Also known as: segmental resection

Level III

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• This retrospective cohort study identified all consecutive patients with T3 (stage IIA to III) adenocarcinoma of the head of the pancreas, who underwent concomitant venous (PV/SMV) resection.

You may not qualify if:

• Those patients with locally advanced tumors that were not responded to neoadjuvant therapy were excluded.

Sponsors & Collaborators

• Sisli Hamidiye Etfal Training and Research Hospital: lead

MeSH Terms

Conditions

Pancreatic Neoplasms

Interventions

Mastectomy, Segmental

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Mastectomy; Surgical Procedures, Operative

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc Prof

Model Details: Anatomical classification was established based on the relationship between portal confluence (PC) and tumor location . Those tumors located superior to the PC were classified as Level I, whereas tumors on the confluence inferiorly located to PC were classified as Level II and Level III.

Study Record Dates

• First Submitted: May 31, 2020
• First Posted: June 4, 2020
• Study Start: May 1, 2014
• Primary Completion: October 1, 2018
• Study Completion: May 1, 2019
• Last Updated: May 11, 2022

Record last verified: 2022-04