Echocardiography in Critically-ill Patients With COVID-19 Pneumonia

NCT04414410 | Unknown

• 1 other identifier: RedCap19
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

Critical care echocardiography (CCE) has been widely used since the 10 last years. Covid outbreak leads that many patients with acute respiratory failure were admitted in the ICU. Many of these patients were ventilated and developed ARDS. Some of them developed deep vein thrombosis and pulmonary embolism. Nothing is already described about the cardiac function and the hemodynamics in these patients (how many RV failure, LV systolic dysfunction,...). The echo group of the cardiodynamix section of European society of intensive care medicien (ESICM) aims to promote CCE and evaluate its interest. The objective is to retrospectively enter in an international database all the echo studies done as usual care in these patients to evaluate (i) incidence of RV failure, (ii) incidence of LV systolic function, (iii) incidence of other patterns. Another objective will be to look for any association between some patterns and respiratory strategy, blood gas analysis, systemic hemodynamics. The echo studies were done and will be reported following one of the recent systematic review published by the same group (Huang S et al. AOIC 2020).

Conditions

COVID; Sars-CoV2

Keywords

critical care echocardiography; COVID; pneumonia; ICU

Outcome Measures

Primary Outcomes (4)

• Incidence of Left ventricular systolic dysfunction

  LV systolic dysfunction is defined as an ejection fraction \< 45%

  Up to 28 days

• Incidence of RV failure

  RV failure is defined as RV/LV end-diastolic area \> 0.8

  up to 28 days

• Incidence of Vasoplegia

  Vasoplegia is defined as a normal or supranormal LV ejection fraction without echocarduiographic signs of hypovolemia.

  Up to 28 days

• Incidence of Hypovolemia

  Hypovolemia is defined as inspiratory collaspe of the superior vena cava in ventilated patients or virtual inferior vena cava in spontaneously breathing patients.

  Up to 28 days

Secondary Outcomes (5)

• Relation between plateau pressure and RV failure

  Up to 28 days

• Relation between tidal volume and RV failure

  Up to 28 days

• Relation between PaO2 and RV failure

  Up to 28 days

• Relation between PaCO2 and RV failure

  Up to 28 days

• Relation between PEEP and RV failure

  Up to 28 days

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

COVID 19 patients admitted in the ICU for respiratory failure.

Sponsors & Collaborators

• Hospital Ambroise Paré Paris: lead

Study Sites (1)

University Hospital Ambroise Pare

Boulogne-Billancourt, Hauts De Seine, 92100, France

Location

Related Publications (1)

• Huang S, Vieillard-Baron A, Evrard B, Prat G, Chew MS, Balik M, Clau-Terre F, De Backer D, Mekontso Dessap A, Orde S, Morelli A, Sanfilippo F, Charron C, Vignon P; ECHO-COVID study group. Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study. Intensive Care Med. 2023 Aug;49(8):946-956. doi: 10.1007/s00134-023-07147-z. Epub 2023 Jul 12.

  PMID: 37436445 DERIVED

MeSH Terms

Conditions

Pneumonia

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Antoine Vieillard-Baron, MD, PhD

  Hospital Ambroise Paré Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 27, 2020
• First Posted: June 4, 2020
• Study Start: May 12, 2020
• Primary Completion: September 30, 2021
• Study Completion: September 30, 2021
• Last Updated: April 29, 2021

Record last verified: 2021-04

Locations

FR (1)